KN-93 | CaMK II 抑制剂 | MCE - MCE-生物活性分子大师
KN-93 (10 μM) 显著抑制高血糖诱导的 CaMKII/NF-κB 信号通路激活，随后降低 Müller 细胞中血管内皮生长因子 、诱导型一氧化氮合酶 和细胞间黏附分子-1 (ICAM-1) 的表达 。
碧云天生物技术-KN-93 Phosphate (CaMK抑制剂)(SD9536-10mM)
在患帕金森病的大鼠模型中，KN-93(5微克)通过降低pGluR1S845的表达改善左旋多巴诱发的异动症。 在MRL/lpr Foxp3-GFP小鼠体内，KN-93引起脾脏，外周淋巴结和外周血中显著的调节 …
KN-93 | CaMK | Autophagy | TargetMol
KN-93是 Ca2+/钙调蛋白依赖性激酶 II (CaMKII) 的选择性抑制剂，Ki 为370 nM，可竞争性阻断 CaM 与激酶的结合。
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美国APExBIO中文官网 - KN-93
kn-93是一种有效的选择性cam激酶ii抑制剂，ic50值为0.37 μm[1]。 cam激酶ii既ca2+-钙调素依赖性蛋白激酶ii，是一种丝氨酸/苏氨酸蛋白激酶，由ca2+/钙调蛋白复合物调节。 camkii有28种 …
KN-93 | C26H29ClN2O4S | CID 5312122 - PubChem
KN-93 is a selective inhibitor of Ca(2+)/calmodulin-dependent protein kinase II. It has a role as an EC 2.7.11.17 (Ca(2+)/calmodulin-dependent protein kinase) inhibitor and a geroprotector. It is …
The KN-93 Molecule Inhibits Calcium/Calmodulin ... - ScienceDirect
2019年3月29日 · KN-93 has been described as an allosteric inhibitor of CaM/CaMKII activity [13]. The first characterization of KN-93 concluded that this molecule was competitive for Ca 2+ …
The KN-93 Molecule Inhibits Calcium/Calmodulin-Dependent ... - PubMed
2019年3月29日 · The molecule KN-93 is the most widely used inhibitor for studying the cellular and in vivo functions of CaMKII. It is widely believed that KN-93 binds directly to CaMKII, thus …
KN-93, an inhibitor of calcium/calmodulin-dependent protein ... - PubMed
Treatment of MRL/lpr Foxp3-GFP mice with KN-93 results in a significant induction of Treg cells in the spleen, peripheral lymph nodes and peripheral blood and this is accompanied by …
KN-93 inhibits IKr in mammalian cardiomyocytes - PubMed
In this study we explore the effect of KN-93 on the rapid component of delayed rectifier potassium current (IKr) in the ventricular myocytes from rabbit and guinea pig hearts. Our data indicate …
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