2019年10月2日 · Here we demonstrate nanopore sensors that map the equilibrium structure of DNA knots, without spurious knot tightening and sliding. We show the occurrence of both tight …

2018年11月2日 · Here, we demonstrate a general strategy to design and construct highly knotted nucleic acid nanostructures, each weaved from a single-stranded DNA or RNA chain by …

2018年5月3日 · Just like any long polymer chain, DNA tends to form knots. Using technology that allows them to stretch DNA molecules and image the behavior of these knots, MIT …

2016年2月18日 · Here we describe principles to guide the folding of highly knotted single-chain DNA nanostructures as demonstrated on a nano-sized square pyramid. Folding of knots is …

2024年7月16日 · We study how different types of tight knots in the DNA segment just outside the pore impact unzipping at different driving forces. We establish three main results. First, knots …

By calculating the writhe of a strand of DNA, biologists can use knot theory to estimate how di cult it will be for enzymes to unpack, unwind, and replicate DNA molecules. For example, after …

2024年10月7日 · DNA knotting is a phenomenon with significant implications in biology and medicine. Understanding how DNA becomes knotted, the enzymes that influence these …

2025年1月9日 · DNA unzipping by nanopore translocation has implications in diverse contexts, from polymer physics to single-molecule manipulation to DNA-enzyme interactions in …

2018年9月9日 · In this article, we use mathematical formalism of θ-curves to characterize the full possibilities of how knotting can occur during replication of DNA molecules in vivo. To do this, …

2017年3月28日 · Here, by using an accurate model, we simulate the translocation of knotted DNA, expose its unexpectedly rich phenomenology, and clarify the implications for …