Kolliphor HS 15 is a yellowish white paste at room temperature that becomes a liquid at approximately 30 °C. It dissolves in water, ethanol and 2-propanol to form clear solutions. Its solubility in water decreases with increasing temperatures.

2012 年,巴斯夫在中国上市了性能卓越的新型增溶剂--Kolliphor® HS 15,国外多个上市产品及临床试验均证明了其具有良好的生理耐受性及其对多种药物强大的增溶能力。 还有研究发现Kolliphor® HS 15可逆转肿瘤细胞对抗癌药物的多药耐药性[3,4]。 Kolliphor® HS 15 的性质不会发生显著变化, 见表表表表1,说明在灭菌过程未发生明显的水解。 对含20% Kolliphor® HS 15 增溶剂与7.5% 维生素E醋酸酯的去离子水溶液进行灭菌,如表表表表2 所示,除 pH值略有变化外, 增溶剂的性质没有 …

2021年10月14日 · Kolliphor(R) HS 15 | C47H94O19 | CID 71311956 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

2019年2月25日 · Kolliphor® HS 15 is an exceptional solubilizer with attributes suited for parenteral and oral formulation of poorly soluble molecules. As a consequence, it is primarily used in screening of new chemical entities (NCEs) and also used as a vehicle in delivery of molecules encapsulated in micelles or micro-emulsions.

teral administration. This is demonstrated by testing haemolytic activity, an assay designed to measure haemolysis (destruction of red blood cells, . 00% considered poor). In this assay, Kolliphor® HS 15 at low concentrations shows no haemolysis, and at 10% exhibited slightly less, yet comparable results to a standard Polysorbate 80 (common pa.

Kolliphor® HS 15 was specifically designed to provide a low immunogenicity during parenteral administration. This is demonstrated by testing haemolytic activity, an assay designed to measure haemolysis (destruction of red blood cells, 100% considered poor). In this assay, Kolliphor® HS 15 at low concentrations shows no haemolysis, and

4 天之前 · Kolliphor ® HS 15是一种强效非离子增溶剂和乳化剂剂，具有低毒性。 是溶解微乳液中低溶解度活性物质的理想之选，它甚至有助于解决最艰巨的溶解难题。

Kolliphor®HS 15 is your highly effective solubilizer and emulsifying agent of choice to formulate poorly soluble APIs in oral and parenteral dosage forms. Newly IID-listed excipient . Low histamine release for fewer side-effects. Thermal stability. Monographed in Ph. Eur. and USP-NF. Product Benefits Product Details.

Kolliphor ® HS 15, a pH-independent non-ionic surfactant, is an effective solubilizer and emulsifying agent. It is soluble in aqueous media and polar organic solvents however it is not soluble in apolar solvents. Its structure has 12-hydroxystearic acid (lipophilic moiety) and polyethylene glycol (hydrophilic moiety).

2021年4月2日 · Kolliphor ® HS 15是一种强效非离子增溶剂和乳化剂剂，具有低毒性。 是溶解 微乳液中 低溶解度活性物质的理想之选 ，它甚至有助于解决最艰巨的 溶解 难题。