MYC and KRAS cooperation: from historical challenges to
2024年8月21日 · RAS and MYC rank amongst the most commonly altered oncogenes in cancer, with RAS being the most frequently mutated and MYC the most amplified. The cooperative …
KRAS Suppression-Induced Degradation of MYC Is …
2018年11月12日 · Acute KRAS suppression caused rapid proteasome-dependent loss of MYC protein, through both ERK1/2-dependent and -independent mechanisms. Surprisingly, MYC …
一文了解癌细胞中 RAS 和 MYC 癌基因之间的相互作用 - 知乎
2024年9月27日 · kras 与 myc 的相互作用还激活了腺苷二磷酸核糖化因子 6 (arf6)，赋予细胞氧化保护能力。 最后，致癌 KRAS 和 MYC 提升了长链非编码 RNA HIF1A-As2、转录因子锌指 E …
KRAS, MYC, and ARF6: inseparable relationships cooperatively …
2023年5月8日 · Mutant KRAS induces MYC gene expression and promotes MYC and ARF6 G4-mRNA translation via increasing eIF4A activity. MYC promotes mitochondrial biogenesis and …
Cancer Cell | KRAS抑制对肿瘤免疫的治疗意义 - 知乎
2024年4月3日 · 在机制上，kras通过上调myc来抑制ifn信号通路直接抑制许多ifn通路基因的表达。 在KRAS突变的肺肿瘤中， MYC的共激活 可通过分泌 CCL9 和 IL-23重塑TME ，导致T细胞 …
GSK3 suppression upregulates β-catenin and c-Myc to abrogate KRas …
2018年12月4日 · Our findings also suggest that during progression of some tumors, mutant KRas may lead to a GSK3α/β-dependent downregulation of β-catenin and/or c-Myc and that …
Myc Cooperates with Ras by Programming Inflammation and …
2017年11月30日 · In a mouse lung model of KRas G12D-driven adenomas, we find that co-activation of Myc drives the immediate transition to highly proliferative and invasive …
Cancer Discovery综述:肿瘤微环境中的代谢相互依赖|Cancer|KRAS|MYC…
2021年9月23日 · il4和il13的受体结合激活了jak1-stat6信号，从而转录上调了myc。myc上调导致关键糖酵解酶hk2和eno1的转录上调。最近的一项研究还表明，kras4a是kras突变的另一种基因 …
precisely KRAS and MYC collaborate in the multifaceted processes that underlie oncogenesis. In this review, we delve into their intricate interplay, providing a
RAS and MYC: Co-conspirators in Cancer - NCI - National Cancer …
2017年7月13日 · Recent studies have demonstrated a critical effector role for MYC: loss of one copy of Myc in a Kras G12D-driven mouse (KPC) model of pancreatic cancer significantly …