再取突破！浙江大学学者揭示Kv4通道复合体门控调制的结构基础
2022年1月8日 · 在 Kv 通道的 12 个亚家族中，Kv4 (Kv4.1–Kv4.3) 通道介导瞬时外向 A 型电流，其特点是在亚阈值膜电位下快速激活、快速失活和从失活状态快速恢复 。 在神经元中，Kv4 位 …
Structural basis of gating modulation of Kv4 channel complexes
2021年9月22日 · Cryo-electron microscopy structures of the voltage-gated potassium channel Kv4.2 alone and in complex with auxiliary subunits (DPP6S and/or KChIP1) reveal the distinct …
Kv4.2 Regulates Basal Synaptic Strength by Inhibiting R-Type …
4 天之前 · Kv4.2 subunits, which mediate transient A-type K+ current, are crucial in regulating neuronal excitability and synaptic responses within the hippocampus. While their contribution …
Regulation of neuronal activity by Cav3-Kv4 channel signaling
2010年2月14日 · We found that T-type calcium channels and Kv4 channels form a signaling complex in rat that efficiently couples calcium influx to KChIP3 to modulate Kv4 function. This …
2023年12月5日 · Kv4.2 by introducing Kv4.2 antibodies into the hippocampal granule cells and evaluated its impact on the baseline synaptic transmission. Our results demonstrated that …
Modulation of Kv4.2 K+ currents by neuronal interleukin-16, a …
2007年8月8日 · In the present study, we provide the following evidence that NIL-16 interacts (either directly or indirectly) with Kv4.2 and reduces Kv4.2 subunit-containing channel current …
Kv4.2 regulates basal synaptic strength by inhibiting R-type …
Kv4.2 subunits, which mediate transient A-type K+ current, are crucial in regulating neuronal excitability and synaptic responses within the hippocampus. While their contribution to activity …
Regulation of Kv4.2 A-type potassium channels in HEK-293
2014年10月13日 · Here, we studied the effects of hypoxia on the function and expression of Kv4.2 and Kv4.3 α subunit channels, which encode rapidly inactivating A-type K currents, in …
Expression of A-type K channel alpha subunits Kv 4.2 and Kv 4.3 …
Voltage-gated K(+) channel alpha subunits Kv 4.2 and Kv 4.3 are the major contributors of somatodendritic A-type K(+) currents in many CNS neurons. A recent hypothesis suggests …
慢性轻度应激通过 Kv4.2 通道的 GSK3β 依赖性调节改变伏隔核中 …
我们澄清，这些小鼠 nac 内活性 gsk3β 水平的增加通过 kv4.2 亚基（a 型 k 的分子决定因素）的磷酸化导致突触可塑性改变+电流。 此外，NAc 中的选择性 GSK3β 沉默可以防止适应不良的突 …
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