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We aimed to evaluate possible roles for pharmacologic astrocyte ablation strategy using La-aminoadipate (L-AAA) on remyelination in a cuprizone model of demyelination. Male C57BL/6 …

本研究调查了 l-α-氨基己二酸 ( l-AA ) 对星形胶质细胞的影响，星形胶质细胞在突触水平感知和响应刺激并调节海马长时程增强 (LTP) 和记忆。 l -AA 对星形胶质细胞的选择性是在 70 年代早期 …

2019年1月16日 · L-a-aminoadipate (L-AAA) is a glutamate homologue working as an astrotoxin for induction of ablation in astrocytes (Khurgel et al. 1996). Astrocyte ablation induced by L …

2021年3月17日 · One of them is the pharmacological ablation of astrocytes by incubating them with the glutamate analogue L-alpha-aminoadipic acid (L-AAA), which causes selective …

The excitotoxin, L-alpha-aminoadipic acid (L-AAA), kills primary astrocytes in the brain. The mechanism underlying the induction of cell death is not well understood although many …

更正为：La-氨基己酸酯 （L-AAA） 诱导的星形胶质细胞消融增强了铜酮脱髓鞘小鼠模型中的髓鞘再生 Metabolic Brain Disease ( IF 3.2) Pub Date : 2023-06-13, DOI: 10.1007/s11011-023 …

2019年4月19日 · In both mice and rats, L-AAA produced a reduction in immunoreactivity of the astrocytic marker glial fibrillary acidic protein (GFAP) for up to 72 h. L-AAA provoked an …

L-α-Aminoadipic Acid is a glutamine synthetase inhibitor. Glutamine synthetase is an enzyme that plays an essential role in the metabolism of nitrogen by catalyzing the condensation of …

We aimed to evaluate possible roles for pharmacologic astrocyte ablation strategy using La-aminoadipate (L-AAA) on remyelination in a cuprizone model of demyelination. Male C57BL/6 …