2024年3月6日 · L1-like metallo-β-lactamases (MBLs) exhibit diversity and are highly conserved. Although the presence of the bla L1-like gene is known, the biochemical characteristics are unclear. This study aimed to characterize an L1-like MBL from Stenotrophomonas lactitubi .

S. maltophilia carries a subclass B3 MBL (L1 enzyme), which is unique among MBLs in having four identical subunits (15), in addition to a chromosomally mediated SBL (L2 enzyme). This combination confers resistance to almost all β-lactams, although MICs vary with methodology, because media affect the expression and/or function of these enzymes (16).

Emergence of Enterobacteriaceae harboring metallo‐β‐lactamases (MBL) has raised global threats due to their broad antibiotic resistance profiles and the lack of effective inhibitors against them. We have been studied one of the emerging environmental MBL, the L1 from Stenotrophomonas maltophilia K279a.

L1-like metallo-β-lactamases (MBLs) exhibit diversity and are highly conserved. Although the presence of the blaL1-like gene is known, the biochemical characteristics are unclear. This study aimed to characterize an L1-like MBL from Stenotrophomonas ...

2008年1月4日 · Here we study the L1 MBL enzyme in apo, mono, and bi-metal states with the goal of providing detailed information at an atomic level regarding its catalytic mechanism, and employ it as a model system to screen inhibitors in crystallo.

2024年10月29日 · This study constructs and analyzes a protein-protein interaction network of L1 beta-lactamase to comprehend its role in the MDR property of the bacteria. The network encompasses 51 proteins including L1 MBL (Smlt2667) and 382 interactions, revealing key players in MDR and potential drug targets.

2019年12月1日 · L1 is a dizinc subclass B3 metallo-β-lactamase (MBL) that hydrolyzes most β-lactam antibiotics and is a key resistance determinant in the Gram-negative pathogen Stenotrophomonas maltophilia, an...

2022年11月30日 · Here, we reveal the structure, binding and cleavage of moxalactam antibiotic bound to L1 metallo-β-lactamase (MBL) from Stenotrophomonas maltophilia.

2023年8月16日 · L1 MBL is one of the most common subclasses of B3 MBL produced by S. maltophilia. Previous studies have demonstrated that L1-like MBLs are highly diverse, with approximately 85% similarity (8, 9). Recently, the reconstruction of bacterial species based on genomic characteristics such as average nucleotide identity (ANI) has been actively discussed.

2019年12月17日 · Emergence of Enterobacteriaceae harboring metallo-β-lactamases (MBL) has raised global threats due to their broad antibiotic resistance profiles and the lack of effective inhibitors against them. We have been studied one of the emerging environmental MBL, the L1 from Stenotrophomonas maltophilia K279a.