免疫调节达人之细胞因子— IL-4 - 知乎 - 知乎专栏
白细胞介素 4（IL-4）是主要由活化的 T 淋巴细胞、肥大细胞、嗜碱性粒细胞产生的一种多效性细胞因子。 1982 年 Howard 发现 T 细胞培养上清中有一种促进 B 细胞增殖的因子，起初命名为 …
IL-4-induced SOX9 confers lineage plasticity to aged adult lung …
2024年7月31日 · Using organoids and mouse models, we show that IL-4 directly acts on a subset of ATIIs to induce the expression of the transcription factor SOX9 and reprograms them …
Genetic variation in IL-4 activated tissue resident ... - Nature
2025年1月25日 · We investigate IL-4 activation of male C57BL/6 and BALB/c strain specific in vivo tissue-resident macrophages (TRMs) from the peritoneal cavity. C57BL/6 TRMs are more …
在做细胞因子检测时，我们经常会测IL-2, IL-4, IL-6, IL-10, TNF, IFN …
碧芯生物推出的Beadstar-mPlex®Human/Mouse Th1/Th2/Th17试剂盒（流式荧光法）可以同时检测这7种细胞因子，相比较于ELISA，整个方法只需要一份样本即可检测多个细胞因子，整个 …
白细胞介素-4 - 维基百科，自由的百科全书
白细胞介素-4诱导B细胞抗体类别转换向IgE，上调第二型 主要组织兼容性复合体 的产生。 这一因子是由M·霍华德、W·保罗和E·委特塔（Vitetta）在1982共同发现的。 四年后人类白细胞介素 …
Diversifying selection and functional analysis of interleukin-4 ...
Interleukin-4 (IL4) is a secreted immunoregulatory cytokine critically involved in host protection from parasitic helminths [1]. Reasoning that helminths may have evolved mechanisms to …
Here, we identify opposing roles of interleukin-4 (IL-4) cytokine signaling in interstitial macrophages and type II alveolar epithelial cells (ATIIs). We show that IL4Ra signaling in …
全面解析！哮喘和特应性皮炎的强势靶点IL-4R - 知乎
白细胞介素-4 （IL-4） 是一种糖基化的I型细胞因子，分子大小约为20kD，具有三个链内二硫键，采用捆绑式四α螺旋结构。 主要由 活化的T细胞、肥大细胞、嗜酸性粒细胞和 嗜碱性粒细胞 …
白细胞介素4受体（IL-4R/IL-4Ra）：细胞因子多功能靶点，哮喘、 …
2024年3月29日 · 白细胞介素-4受体（IL-4R，又叫CD124；IL4Rα）是一种I型跨膜蛋白，属于白细胞介素家族成员之一。 IL4Rα链cDNA全长3.6 kb，含有一个编码825个氨基酸的开放阅读框 …
Interleukin 4 - Wikipedia
The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (T h 0 cells) to T h 2 cells. Upon activation by IL-4, T h 2 cells subsequently produce additional IL-4 in …
Recent advances in understanding the role of IL-4 signaling
IL-4 is critical not only for careful control of immunoglobulin production but also related to inflammation, fibrosis, allergic reactions, and antitumor activity, with actions of IL-4 occurring …
Regulation of inflammation by interleukin-4: a review of …
Studies of IL-4 have revealed a wealth of information on the diverse roles of this cytokine in homeostatic regulation and disease pathogenesis. Recent data suggest that instead of simple …
Healing action of Interleukin-4 (IL-4) in acute and chronic ...
2025年1月1日 · Interleukin-4 (IL-4), which is traditionally associated with inflammation, has emerged as a key player in tissue regeneration. Produced primarily by T-helper 2 (Th2) and …
Remodeling of Il4-Il13-Il5 locus underlies selective gene expression
2024年11月20日 · Physical proximities among REs were coordinately remodeled in three-dimensional space after cell activation, leading to divergent compartmentalization of Il4, Il13 …
An IL-4 signalling axis in bone marrow drives pro-tumorigenic ...
2023年12月6日 · Our study defines a central role for IL-4 in controlling immunosuppressive myelopoiesis in cancer, identifies a novel combination therapy for immune checkpoint …
Recent advances in understanding the role of IL-4 signaling
2021年9月7日 · IL-4 is critical not only for careful control of immunoglobulin production but also related to inflammation, fibrosis, allergic reactions, and antitumor activity, with actions of IL-4 …
Regulation of IL-4 Expression in Immunity and Diseases
It is a signature cytokine of type 2 immune response but also has a nonimmune function. Its expression is tightly regulated at several levels, including signaling pathways, transcription …
The epigenetic state of IL-4-polarized macrophages enables
2022年11月8日 · Our findings establish that IL-4-induced epigenetic reprogramming is responsible for the development of inflammatory hyperresponsiveness to TLR activation and …
Locus of (IL-9) control: IL9 epigenetic regulation in cellular
2024年6月3日 · IL-9 has diverse sources that include CD4 + T cells, CD8 + T cells, innate lymphoid cells (ILCs), mast cells, and basophils 1. While the sources and functions of IL-9 are …