2022年2月1日 · LAT1 regulates cell proliferation upstream of mTORC1. In addition to inhibiting mTORC1, LAT1 inhibitors activate the GAAC pathway to suppress translation initiation. LAT1 …

5 天之前 · Heteromeric amino acid transporters (HATs), including y + LAT1-4F2hc complex, are responsible for transporting amino acids across membranes, and mutations in y + LAT1 cause …

2024年10月19日 · Glioblastoma, a fatal brain cancer with limited treatments and poor prognosis, could benefit from targeting the L-type amino acid transporter I (LAT1). LAT1 is essential for …

2016年10月15日 · Large neutral amino acid transporter 1 (LAT1) is a solute carrier protein located primarily in the blood–brain barrier (BBB) that offers the potential to deliver drugs to the brain. …

2020年3月30日 · We characterized the role of LAT1 by determining whether the inhibition of LAT1 activity reduces the penetration of LAAM TC-CQDs in an in vitro BBB model as well as in vivo …

2015年4月13日 · L-type amino acid transporter 1 (LAT1), overexpressed on the membrane of various tumor cells, is a potential target for tumor-targeting therapy. This study aimed to …

5 天之前 · Heteromeric amino acid transporters (HATs), including y+LAT1- 4F2hc complex, are responsible for transporting amino acids across membranes, and mutations in y+LAT1 cause …

2017年3月2日 · In this review, we present current information on amino-acid transporters, such as LAT1 (l -leucine transporter), ASCT2 (l -glutamine transporter) and GAT-1 (γ -aminobutyric …

2024年9月1日 · The paracellular AA flux except for Ser, Thr, Tyr, Ala, and Gly was enhanced by CLDN1 silencing. These results suggest that CLDN1 forms a paracellular barrier to some AAs, …

2020年9月22日 · Two sodium independent transport systems, LAT1 or L, and y +, mediate the facilitated exchange of large neutral AAs (both systems) and basic AAs (y +) in both luminal …