Increasing the uptake of leucine into cells is the most effective way that LAT1 promotes the activity of Mechanistic Target of Rapamycin Kinase Complex 1 (mTORC1). LAT1 not only supports mTORC1 activity, it also reinforces MYC and EZH2 signaling in cancer cells. We will review these LAT1-supported downstream effects.

2022年2月1日 · The inhibition of LAT1 suppresses protein synthesis by downregulating the mTORC1 signaling pathway and mobilizing the general amino acid control (GAAC) pathway in cancer cells. LAT1 is, thus, a candidate molecular target …

2020年1月28日 · JPH203 inhibited phosphorylation of MAPK / Erk, AKT, p70S6K and 4EBP-1. Multivariate analysis revealed that high LAT1 expression was found as an independent prognostic factor for overall...

2021年10月11日 · The l-type amino acid transporter 1 (LAT1) is a membranous transporter that transports neutral amino acids for cells and is dysregulated in various types of cancer. Here, we first observed increased LAT1 expression in pemetrexed-resistant non-small cell lung cancer (NSCLC) cells with high cancer ste …

2019年7月7日 · The LAT1-mTORC1 axis (red dashed square) inhibits the activation of Akt, thus preventing GSK3β from stimulating the translocation of NFATc1 from the nucleus to the cytoplasm. LAT1-mTORC1 signaling also inhibits the activation of IKK and IκBα in osteoclasts, thus preventing the degradation of IκB and the nuclear translocation of the p65 and ...

LAT1 对癌细胞生长至关重要，因为 LAT1 的药理学抑制和敲低/敲除可抑制癌细胞的增殖和异种移植肿瘤的生长。 LAT1 的抑制通过下调 mTORC1 信号通路和调动癌细胞中的一般氨基酸控制 (GAAC) 通路来抑制蛋白质合成。 因此，LAT1 是癌症诊断和治疗的候选分子靶标。 由于 α-甲基芳香族氨基酸的 LAT1 特异性， 18 F-标记的 3-氟 -1 -α-甲基-酪氨酸 (FAMT) 被用作 LAT1 特异性 PET 探针用于癌症检测。 FAMT 积累是癌症特异性的，可以避免非癌症病变，包括炎症，证实 …

2023年10月23日 · Taken together, lysosomal LAT1 recruits and activates the mTORC2 complex and downstream Akt for PMA-mediated cell migration. These results provide insights into the development of therapeutic drugs targeting the LAT1 amino acid transporter to block metastasis, as well as disease progression in various types of cancer.

The inhibition of LAT1 suppresses protein synthesis by downregulating the mTORC1 signaling pathway and mobilizing the general amino acid control (GAAC) pathway in cancer cells. LAT1 is, thus, a candidate molecular target for the diagnosis and therapeutics of cancers.

2014年12月8日 · Our results show that overexpressed LAT1 on T-ALL/T-LL cancer cells reflects a cancer addiction towards increased nutrients uptake for mTORC1 and Akt activation and reprogrammed metabolism that...

2025年2月15日 · 该研究对于深入理解氨基酸转运蛋白 LAT1（L-type amino acid transporter 1，L 型氨基酸转运蛋白 1）在癌症治疗、免疫反应以及药物递送等方面的作用机制具有重要意义，为开发更有效的抗癌药物和治疗策略提供了关键的结构基础。 氨基酸转运蛋白对于维持细胞内氨基酸稳态至关重要，它参与多种代谢和信号通路。 其中，LAT1（SLC7A5）具有广泛的底物特异性，不仅能运输必需的中性氨基酸（如 L -Leu、L -Phe）、碱性氨基酸（L -His）、非必需中性氨基 …