LAT1 and Blood–Brain Barrier: Structural and Functional Aspects
2024年9月26日 · L-type amino acid transporter 1 (LAT1) is integral to the transport of large neutral amino acids across the blood–brain barrier (BBB), playing a crucial role in brain homeostasis and the delivery of therapeutic agents.
L-Type amino acid transporter 1 as a target for drug delivery
In this respect, the L-type amino acid transporter 1 (LAT1, SLC7A5), which is expressed at a relatively high level at the blood-brain barrier (BBB), blood-retinal barrier (BRB), testis, bone marrow, placenta and several types of human tumour …
l-Type Amino Acid Transporter 1 (LAT1/Lat1)-Utilizing Prodrugs
2019年9月6日 · l-Type Amino Acid Transporter 1 (LAT1/Lat1) is responsible for carrying large, neutral l-amino acids as well as several drugs and prodrugs across the blood-brain...
“脑癌”潜力靶点LAT1，药物设计思路清晰 - 网易
2021年9月30日 · lat1于bbb系统的特点. bbb作为cns与血液中物质交换的屏障结构，主动摄取cns所需的营养物质，并外排或阻挡有损cns的物质进入，以保障cns的生理稳态。 bbb的这一屏障功能同样也阻碍了大部分“治脑”药物进入脑组织，严重影响cns疾病的治疗。
Transport of Amino Acids Across the Blood-Brain Barrier
2020年9月22日 · At the BBB, LAT1 is stereospecific (L > D), catalyzes an exchange (in 1:1 stoichiometry) of two AAs and is inhibited by BCH [2-aminobicyclo-(2,2,1) heptane-2-carboxylic acid], an amino acid-related compound that has been used as a selective inhibitor of the system L amino acid transporters.
A new shuttle for drug delivery across the blood–brain barrier
2023年11月3日 · In the current study, Pornnoppadol et al. selected the heavy chain of LAT1, termed CD98hc, as a potential target for shuttling across the BBB. CD98hc is highly expressed on mouse and human...
L-Type Amino Acid Transporter 1 Enables the Efficient Brain
2020年12月16日 · Because L-type amino acid transporter 1 (LAT1) is a good candidate to improve the brain delivery, we developed here four novel LAT1-utilizing prodrugs of four nonsteroidal anti-inflammatory drugs. As a result, all the prodrugs were able to cross the BBB and localize into the brain cells.
The Multifaceted Role of L-Type Amino Acid Transporter 1 at
2024年9月26日 · L-type amino acid transporter 1 (LAT1) is integral to the transport of large neutral amino acids across the blood-brain barrier (BBB), playing a crucial role in brain homeostasis and the delivery of therapeutic agents. This review explores the multifaceted role of LAT1 in neurological disorders, inc …
[LAT1/solute carrier type 7A5（SLC7A5）]は， Leu,Ile,Phe,Met,Tyr,His,Trp,Valなどの大型中 性アミノ酸の取り込みをNa＋に非依存的に細胞膜 において交換輸送する．LAT1 は，正常な生体では 血液脳関門（blood brain barrier; BBB），血液網膜
深入了解大型中性氨基酸转运蛋白 1 (LAT1) 的结构、功能和配体发 …
大中性氨基酸转运蛋白 1（lat1 或 slc7a5）是一种不依赖钠和 ph 的转运蛋白，为细胞提供必需氨基酸（例如亮氨酸、苯丙氨酸）。 它在血脑屏障 (BBB) 中发挥着重要作用，促进甲状腺激素、药物（例如左旋多巴、加巴喷丁）和代谢物转运至大脑。