2014年12月8日 · The current study demonstrates that inhibiting LAT1/SLC7A5, an essential amino-acid (EAA) transporter, alters metabolism and survival of ALL/T-LL cellular models such as primary cells and cell...

lat1 对癌细胞生长至关重要，因为 lat1 的药理学抑制和敲低/敲除可抑制癌细胞的增殖和异种移植肿瘤的生长。 LAT1 的抑制通过下调 mTORC1 信号通路和调动癌细胞中的一般氨基酸控制 (GAAC) 通路来抑制蛋白质合成。

2021年9月30日 · LAT（L-type amino transporters），即L型氨基酸转运体，主要功能为中性氨基酸包括必须氨基酸的转运，亚型按照时间发现顺序依次为LAT1、LAT2、LAT3、LAT4，其中LAT1的研究相对最多。

2013年10月15日 · In this study, we show that L-type amino acid transporter 1 (LAT1) is a major transporter for essential amino acids into activated human T cells. CD3/CD28 stimulation in primary human T cells triggered dramatic induction of …

2017年12月26日 · LAT1/SLC7A5 is a transmembrane amino-acid transporter, which imports leucine and other BCAAs into cells in exchange for glutamine. This places LAT1 as a central regulator of skeletal muscle protein dynamics given the importance of leucine in activating mTORC1 and initiating MPS after feeding .

2015年5月22日 · We show that LAPTM4b recruits LAT1-4F2hc to lysosomes, leading to uptake of Leu into lysosomes, and is required for mTORC1 activation via V-ATPase following EAA or Leu stimulation. These...

2025年2月15日 · 德国马克斯?普朗克生物物理研究所（Department of Structural Biology, Max Planck Institute of Biophysics）的 Yongchan Lee 等人在《Nature Communications》期刊上发表了题为 “Structural basis of anticancer drug recognition and amino acid transport by LAT1” 的论文。 该研究对于深入理解氨基酸转运蛋白 LAT1（L-type amino acid transporter 1，L 型氨基酸转运蛋白 1）在癌症治疗、免疫反应以及药物递送等方面的作用机制具有重要意义，为开发更有效 …

2019年7月7日 · Amino acid substrates of LAT1 are suggested to have a beneficial impact on bone health directly and indirectly. For example, EAA supplements that include Leu and Ile increase bone strength through modification of bone mineral density and bone microarchitecture in ovariectomized osteoporotic rats fed a low-protein diet .

LAT1 was pharmacologically blocked by JPH203 in human ATC and papillary thyroid cancer (PTC) cell lines. The effects on proliferation and mTORC1 activity were addressed in vitro. A genetically engineered mouse model of ATC was used to address the effect of blocking LAT1 on tumor growth in vivo.

L-type amino acid transporter-1 （LAT1） is a member of the sodium-independent amino acid transport system L and transports large branched-chain and aromatic neutral amino acids. LATI is normally expressed in fetal liver, bone marrow, brain, placenta, and testes.