Atg8/LC3 is cleaved by ATG4(B) protease to expose a C-terminal glycine residue. Cleaved LC3 is then conjugated to phosphatidylethanolamine (PE) by sequential activation of Atg7 (E1-like …

LC3 is synthesized as a precursor form that is cleaved by the protease ATG4B, resulting in the cytosolic isoform LC3-I. In turn, LC3-I is conjugated to phosphatidylethanolamine (PE) to form …

2019年7月12日 · Here we find that the endogenous LC3-positive puncta become larger in cells where autophagosome formation is abrogated, and are prominent even when LC3-II is not …

2009年3月26日 · Similar to the Atg8 system in yeast, the C‐terminal peptide of LC3 is cleaved by mammalian Atg4 homologues (Hemelaar et al, 2003; Marino et al, 2003; Kabeya et al, 2004; …

2006年1月6日 · Rat microtubule-associated protein light chain 3 (LC3) is a homologue of yeast Atg8, an essential component of autophagy. Following synthesis, the C-terminus of rat LC3 is …

2006年1月6日 · Rat microtubule-associated protein light chain 3 (LC3) is a homologue of yeast Atg8, an essential component of autophagy. Following synthesis, the C-terminus of rat LC3 is …

Microtubule-associated protein 1A/1B-light chain 3 (LC3) is a soluble protein with a molecular mass of approximately 17 kDa that is distributed ubiquitously in mammalian tissues and …

2004年12月1日 · The carboxyl termini of the pro-forms of LC3, GABARAP, and GATE-16 are cleaved by hAtg4B (or hAtg4A for proGATE-16) to expose Gly, and the resultant LC3-I, …

2004年6月1日 · Rat LC3, a homologue of yeast Atg8 (Aut7/Apg8), localizes to autophagosomal membranes after post-translational modifications. The C-terminal fragment of LC3 is cleaved …

2015年9月17日 · The form LC3-II is one of the main components of the autophagosome membrane (LC3A-II and LC3B-II, also LC3C-II but not studied here) that resides in both the …