Keywords: Autophagy; LC3A; SOX2; cancer cell plasticity; lung cancer; mitochondria dynamics. This work was supported by National Tsing Hua University and Ministry of Science and …

2025年2月1日 · Research indicates that LC3B can act as a positive regulator of apoptosis in lung epithelial cells. Tanaka et al. discovered that LC3B enhances cell survival by engaging with …

2023年6月1日 · We defined imminent lung cancer as a clinical lung cancer diagnosis within three years of blood draw and identified 731 lung cancer cases and 731 smoking-matched controls …

With more than 3 million longitudinally followed research participants and 70 000 incident lung cancer cases included in the centralized database, the LC3 provides an unprecedented …

5 天之前 · We also found that CTL impaired autophagic flux and promoted the conversion of light chain 3 (LC3)-I to its lipid-conjugated form, LC3-II, thereby inducing autophagosome …

2023年6月20日 · In CHI3L1-overexpressing lung cancer cells, the expression of LC3, an autophagosome marker, and the accumulation of LC3 puncta increased. In contrast, CHI3L1 …

Both mRNA and protein levels of Beclin-1 and LC3-II were significantly decreased in lung cancer tissues which suggested that autophagy may be involved in the pathogenesis of lung cancer.

2015年9月17日 · LC3s (MAP1-LC3A, B and C) are structural proteins of autophagosomal membranes, widely used as biomarkers of autophagy. Whether these three LC3 proteins have …

Results: The formation of autophagosomal protein LC3-II progressively accumulated in the lungs over 24 hours after CLP, with the Lc3 gene expression returning to baseline levels at 24 hours. …

We characterized how LC3A links mitochondrial metabolism and degradation to SOX2-mediated proliferation and dissemination in lung cancer cells. Lung cancer is under autophagy addiction, …