Microtubule-associated proteins 1A/1B light chain 3B (hereafter referred to as LC3) is a protein that in humans is encoded by the MAP1LC3B gene. [5] LC3 is a central protein in the autophagy pathway where it functions in autophagy substrate selection and autophagosome biogenesis .

2024年12月25日 · MAP1LC3B (Microtubule Associated Protein 1 Light Chain 3 Beta) is a Protein Coding gene. Diseases associated with MAP1LC3B include Pancreatic Ductal Adenocarcinoma and Smith-Mccort Dysplasia 2. Among its related pathways are Early SARS-CoV-2 Infection Events and Selective autophagy.

2025年2月1日 · The phosphorylation of LC3B enhances autophagy by promoting the fusion of autophagosomes with lysosomes. Additionally, LC3B functions as an RNA-binding protein that triggers mRNA degradation, thus initiating autophagy. Furthermore, as a transcriptional co-factor, LC3B influences gene expression to support autophagy.

Microtubule-associated protein 1A/1B-light chain 3 (LC3) is a soluble protein with a molecular mass of approximately 17 kDa that is distributed ubiquitously in mammalian tissues and cultured cells. During autophagy, autophagosomes engulf cytoplasmic components, including cytosolic proteins and organelles.

2025年2月16日 · Data show that TFDP3 upregulates the expression of autophagy gene LC3B and inhibits E2F1-induced apoptosis, and may play an important role in prostate cancer. In solid tumors, high LC3B expression was associated proliferation, invasion and metastasis, high nuclear grade, and worse outcome.

2022年3月17日 · In this study, we demonstrate that LC3B, a central protein in autophagy, is an RBP with a binding preference for the AAUAAA consensus motif. Direct binding of LC3B to mRNAs elicits rapid...

Microtubule-associated protein 1 light chain 3B (MAP1LC3B, also known as LC3B) is a mammalian homolog of the autophagy-related protein 8 (ATG8) family. It plays a crucial role in cellular autophagy and is involved in several vital biological processes, including apoptosis and …

2025年3月5日 · Increased LC3B expression and LC3B gene promoter hypermethylation may serve as biomarkers for progression of M. tb infection, while use of de-methylation agent may be a potential approach to host-directed immunotherapy in active TB disease.

2025年1月13日 · p62/LC3b complex regulates lung alveolar epithelial cell homeostasis and cytoprotection after hyperoxia. Lc3 over-expression improves survival and attenuates lung injury through increasing autophagosomal clearance in septic mice. LC3B plays a regulatory role in hyperoxia-induced epithelial apoptosis

该基因的产物是神经元微管相关 MAP1A 和 MAP1B 蛋白的亚基，它们参与微管组装，对神经发生很重要。 对大鼠同系物的研究暗示了该基因在自噬中的作用，自噬是一种涉及细胞质成分大量降解的过程。 [RefSeq 提供，2008 年 7 月] The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis.