LGR4 is a receptor for RANKL and negatively regulates osteoclast ...
2016年4月11日 · LGR4 has been identified as a new receptor for RANKL in bone cells where it opposes RANK signaling to inhibit osteoclasts differentiation, and its therapeutic targeting …
LGR4 Gene - GeneCards | LGR4 Protein | LGR4 Antibody
2024年12月25日 · LGR4 (Leucine Rich Repeat Containing G Protein-Coupled Receptor 4) is a Protein Coding gene. Diseases associated with LGR4 include Delayed Puberty, Self-Limited …
Nature子刊：陈佺、杜蕾、胡刚团队通过靶向LGR4激活癌细胞铁 …
2024年1月31日 · 研究团队开发了靶向LGR4的单克隆抗体——LGR4-mAb，其可有效抑制LGR4-Wnt信号转导，与化疗药物联用时可显著增强化疗耐药的肿瘤类器官的铁死亡，从而为对抗难 …
LGR4，一种具有系统作用的 G 蛋白偶联受体：从 ... - X-MOL
Leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4/GPR48), a member of the GPCR (G protein-coupled receptors) superfamily, subfamily B, is a common intestinal crypt …
Circ Res:巨噬细胞膜受体Lgr4参与急性心肌梗死后 ... - MedSci
2020年7月28日 · 该研究首次发现富含亮氨酸重复序列的G蛋白偶联受体（leucine-rich repeat-containing G protein-coupled receptor，LGR）家族成员Lgr4调控巨噬细胞促炎激活参与心肌梗 …
LGR4 - Wikipedia
Leucine-rich repeat-containing G-protein coupled receptor 4 is a protein that in humans is encoded by the LGR4 gene. [5] [6] LGR4 is known to have a role in the development of the …
LGR4基因的功能与作用机制解析 - 八方基因
2024年12月19日 · 本文将详细介绍LGR4基因的功能、作用机制、信号通路及其与疾病的关系，帮助读者全面理解这一重要的G蛋白偶联受体。 LGR4基因概述 LGR4，全名 leucine rich repeat …
Emerging Roles for LGR4 in Organ Development, Energy …
LGR4 is a transmembrane receptor of the GPCRs superfamily that is characterized by a large extracellular Leucine-rich domain that recognizes and interacts with its ligands (Van Loy et al., …
LGR4: A New Receptor Member in Endocrine and Metabolic …
2023年7月11日 · LGR4 is a new member of this G protein-coupled receptor family and shows ways of expression and function similar to those of LGR1/2/3. Several recent studies have …
LGR4 在器官发育、能量代谢和致癌作用中的新作用,Frontiers in …
富含亮氨酸的重复序列包含属于 G 蛋白偶联受体 (GPCRs) 家族的 G 蛋白偶联受体 4 (LGR4)，在多种细胞类型和众多靶向位点具有多种调节作用，异常的 LGR4 信号传导在疾病和致癌。 基 …