Luteinizing hormone (LH) and human chorionic gonadotropin (hCG) serve different roles in reproductive physiology: LH contributes to the driving force behind gonadal steroidogenesis and regulation of ovulation, whereas hCG (in the absence of pathologic abnormalities) is secreted in large amounts only during pregnancy .

2023年5月16日 · Three key hormones that play vital roles in fertility are luteinizing hormone (LH), pregnanediol glucuronide (PdG), and human chorionic gonadotropin (hCG). In this blog, we’ll explore the hormonal relationship between these hormones and their significance in …

2014年3月5日 · Emerging data suggest that these differences between LH and hCG have functional significance. Identifying the unique roles of LH and hCG is key to understanding both normal physiologic processes (e.g., reproduction, placentation) and dysfunctional states (e.g., infertility, gestational and non-gestational neoplasms).

Whereas LH is a key regulator of gonadal steroidogenesis and ovulation, hCG is predominantly active in pregnancy and fetal development. Emerging evidence has revealed endogenous functions not previously ascribed to hCG, including participation in ovulation and fertilization, implantation, placentation and other activities in support of ...

LH and hCG play essential roles in the reproductive cycle. LH plays a key role in follicular maturation and the ovulation process, and hCG is the “pregnancy hormone.” LH and hCG are different in terms of structure, expression, regulation, and function. LH and hCG fundamentally differ in their expression patterns and have complex and unique aspects.

In addition to LH supplementation using recombinant LH, several studies have used human chorionic gonadotrophin (hCG), a hormone with LH activity.

2017年4月19日 · Our data indicate that rhLH and rhCG differentially promote cell responses mediated by LH/CGR revealing interesting divergences in their potencies, efficacies and kinetics: rhCG was more potent...

2020年8月6日 · This review summarises the molecular and functional differences between hCG and LH, and provides an overview of the clinical trial data surrounding the use of products for OS that contain LH bioactivity, examining their individual effect on outcomes such as endometrial receptivity, oocyte yield and embryo quality, as well as key pregnancy outcomes.

2024年2月24日 · Luteinizing hormone (LH) works alongside FSH to trigger follicle growth and the release of an egg. FSH and LH both act on the follicular cells, leading to a shut-off of the processes that usually limit LH production. Levels of LH increase sharply, encouraging the follicle to release the egg [4].

Human luteinizing hormone (hLH) and chorionic gonadotropin (hCG) act on the same receptor (LHCGR) but it is not known whether they elicit the same cellular and molecular response. This study compares for the first time the activation of cell-signalling pathways and gene expression in response to hLH and hCG.