2024年12月25日 · LIN28B (Lin-28 Homolog B) is a Protein Coding gene. Diseases associated with LIN28B include Acrocephalopolysyndactyly Type Iii and Neuroblastoma. Among its related pathways are Hippo-Merlin signaling dysregulation and Pleural mesothelioma. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding.

Lin-28 homolog B is a protein that in humans is encoded by the LIN28B gene. [5] The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains.

Mutations in LIN28B are associated with precocious puberty. [ 17 ] LIN28 can regulate glucose homeostasis in mammals by increasing insulin - PI3K - mTOR signaling and insulin sensitivity, thereby promoting resistance to high fat diet-induced obesity and type 2 diabetes . [ 18 ]

2018年8月31日 · LIN28B is an evolutionarily conserved RNA-binding protein that regulates mRNA translation and miRNA let-7 maturation in embryonic stem cells and developing tissues. Increasing...

2025年2月8日 · Title: LIN28B promotes differentiation of fully transformed AML cells but is dispensable for fetal leukemia suppression. A Multi-Omics Approach Reveals Enrichment in Metabolites Involved in the Regulation of the Glutathione Pathway …

2021年10月27日 · Here, we demonstrate that Lin28B promotes lung metastasis of breast cancer by building an immune-suppressive pre-metastatic niche. Lin28B enables neutrophil recruitment and N2 conversion. The...

2023年6月15日 · Here, we determine the high-resolution structures of the nucleosome containing human LIN28B DNA and its complexes with the OCT4 DNA binding region. Three OCT4s bind the pre-positioned nucleosome by recognizing non-canonical DNA sequences.

2025年1月5日 · Lin28B is a novel marker for predicting prognosis in patients with oral squamous cell carcinoma; Lin28B is an oncofetal circulating cancer stem cell-like marker associated with recurrence of hepatocellular carcinoma. Genetic variants of LIN28B may be biomarkers for susceptibility to severe radiation pneumonitis in non-small cell lung cancer ...

The human paralogs Lin28a (routinely termed simply Lin28) and Lin28b encode for basic 23- or 28-kDa proteins that are highly expressed in embryonic stem cells (ESC) but are down-regulated upon differentiation of ESCs into embryoid bodies .

2024年12月12日 · To functionally validate the interaction between LIN28B and PBX3 mRNA, we modulated LIN28B levels in esophageal cancer cells through transfecting with LIN28B overexpression or silence vector (Figure 5F). Remarkably, LIN28B overexpression enhanced the stability of PBX3 mRNA, while its knockdown exerted the opposite effect (Figure 5G).