2015年1月4日 · 是诊断ii型自身免疫性肝炎的血清学指标，靶抗原为lkm-1(细胞色素p450iid6)、lkm-2、lkm-3和肝微粒体。 自身免疫性肝炎按血清学标志至少可分为三型：Ⅰ型（“狼疮样”肝炎）以出现抗核抗体(ANA)、平滑肌抗体(ASMA)、肝细胞膜抗体(LMA抗体)为特征；Ⅱ型以出现LKM抗体 ...

Liver kidney microsomal type 1 antibody (anti-LKM1) is an autoantibody associated with autoimmune hepatitis (AIH). [1] Specifically, its presence in AIH defines type 2 AIH, [2] [3] although it has been proposed that anti-liver cytosol type 1 autoantibody without detectable anti-LKM1 can be seen in type 2 AIH. [4]

抗LKM-1抗体为AIH- II型血清特异性抗体，敏感性为90%，在AIH中检出率较低 (约10%左右)。 慢性丙型肝炎 患者中约 2%-10%也可检测到抗LKM-1抗体。 AIH中抗LKM-1抗体阳性患者，较多具有典型的自身免疫现象，大多为青年女性，自身抗体滴度较高，血清免疫球蛋白显著增高，病情比较严重，对激素治疗反应好，欧美地区多见；HCV感染伴有抗LKM-1抗体阳性患者，大多年龄较大，女性并不多见，自身抗体滴度较低，血清免疫球蛋白不高，病情为慢性肝炎表现，对干扰素 …

2021年6月6日 · Liver Kidney Microsomal (LKM-1) Antibody (IgG) The presence of LKM-1 antibodies can be used in conjunction with clinical findings and other laboratory tests to aid in the diagnosis of autoimmune liver diseases such as autoimmune hepatitis (AIH-2) .

Liver Kidney Microsomal (LKM-1) Antibody (IgG) The presence of LKM-1 antibodies can be used in conjunction with clinical findings and other laboratory tests to aid in the diagnosis of autoimmune liver diseases such as autoimmune hepatitis (AIH-2) .

The detection of LKM-1 antibodies is an aid in the diagnosis of autoimmune hepatitis, type 2 (AIH-2). LKM antibodies are markers of AIH-2 which usually begins in childhood and generally affects children younger than 18 years of age. LKM antibodies are associated with a more serious progression of the disease.

Liver Kidney Microsomal (LKM-1) Antibody (IgG) - The presence of LKM-1 antibodies can be used in conjunction with clinical findings and other laboratory tests to aid in the diagnosis of autoimmune liver diseases such as autoimmune hepatitis (AIH-2).

Differential evaluation of autoimmune liver disease of unknown etiology, especially autoimmune hepatitis (AIH) of childhood onset. Use in combination with Liver Cytosolic Antigen Type 1 (LC-1) Antibody, IgG when evaluating for AIH-2.

2024年2月21日 · 抗lkm-1是i型aih的标志抗体，i型aih患者多为青年女性伴高免疫球蛋白血症，病情较重，抗lkm-1抗体阳性率可达90%。 此外，抗LKM-1抗体也可见于2% ~10%的慢性 丙型病毒性肝炎 患者。

是诊断ii型自身免疫性肝炎的血清学指标，靶抗原为lkm-1(细胞色素p450iid6)、lkm-2、lkm-3和肝微粒体。 应用学科 免疫学（一级学科），免疫系统（二级学科），免疫分子（三级学科）