Aug 2, 2021 · Emerging evidence suggests that liquid–liquid phase separation (LLPS) represents a vital and ubiquitous phenomenon underlying the formation of membraneless organelles in eukaryotic cells...

Sep 4, 2024 · What Is a Limited Liability Partnership (LLP)? A limited liability partnership (LLP) is a flexible legal and tax entity where every partner has a limited personal liability for the debts...

This review will summarize the principle and components of LLPS, and describe how LLPS regulate these numerous biological processes and disruption of LLPS would cause disease formation. The role of LLPS in regulating normal cellular physiology and contributing to tumorigenesis will be discussed.

Dec 1, 2023 · Liquid-liquid phase separation (LLPS) is a captivating phenomenon in which a uniform mixture spontaneously divides into two liquid phases with differing component concentrations.

Feb 11, 2022 · Liquid–liquid phase separation (LLPS) has been revealed as a widespread mechanism underlying the spatiotemporal coordination of biological activities in cells.

Jul 8, 2022 · Liquid–liquid phase separation (LLPS) is a novel principle for explaining the precise spatial and temporal regulation in living cells. LLPS compartmentalizes proteins and...

Oct 21, 2021 · Su et al. review the broad impact of liquid-liquid phase separation (LLPS) on various cellular processes and signaling pathways, emphasizing the spatiotemporal regulation of cell signaling by LLPS and the underlying molecular mechanisms involved.

Dec 1, 2024 · LLPS is involved in a variety of physiological activities, and abnormal LLPS behavior can lead to various diseases. Detecting the phase separation parameters can identify the disease type and provide effective treatments to …

Dec 16, 2022 · Liquid–liquid phase separation (LLPS) compartmentalizes kinases, substrates, and cofactors to promote substrate selectivity and spatiotemporal control of signaling events. Some kinases can act as scaffolds for phase separation, whereas others act as clients that depend on the LLPS properties of scaffolds.

Evidence is now mounting that liquid-liquid phase separation (LLPS) or condensation underlies the formation of membraneless bodies such as nucleoli in cells. The list of cell compartments thought to be formed via the process of LLPS is growing rapidly and …