
技术专题 | 液-液相分离 (LLPS):现代生物医学中的新前沿【珍藏】 …
RAP80与Lys63连接的多聚泛素链的结合增加了多价相互作用,从而诱导RAP80在DNA损伤位点的液液相分离(LLPS)。 同时发现,RAP80 LLPS增强了肿瘤细胞的放疗抵抗性,表明RAP80 …
Functional specificity of liquid-liquid phase separation at ... - Nature
2024年11月21日 · LLPS is a process by which liquid condensates enriched in specific protein-protein or protein-nucleic acid complexes separate from a de-enriched dilute phase, creating …
Liquid–liquid phase separation in human health and diseases
2021年8月2日 · Emerging evidence suggests that liquid–liquid phase separation (LLPS) represents a vital and ubiquitous phenomenon underlying the formation of membraneless …
一文读懂相分离(图文详解) - 知乎
一共两种相,即水和油,由于都是液体,也叫 液液相分离 (LLPS,liquid-liquid phase separation)。 回顾下我们幼儿园学过的知识: 生物进化过程中,在细胞内会用膜分割一些 …
Liquid-liquid phase separation (LLPS) in cellular physiology and …
2021年8月15日 · Liquid-liquid phase separation (LLPS) has emerged as a mechanism that has been used to explain the formation of known organelles (e.g. nucleoli, promyelocytic leukemia …
Cell | 吴皓/朱书团队揭示相分离在肠道和肝脏NLRP6炎症小体激活 …
在过去的几年中,越来越多的证据表明液液相分离(Liquid-Liquid Phase Separation,LLPS)参与了多种细胞过程,这些无膜液滴状的成分(如核仁、应激颗粒等)在没有膜的束缚下依然可以 …
DrLLPS - Data resource of LLPS
Phase separation, or liquid-liquid phase separation (LLPS), is a ubiquitous and important mechanism for the formation of membraneless condensates in cells. LLPS is driven by …
液-液相分离 (LLPS):现代生物医学中的新前沿_技术资料_丁香通
液-液相分离(Liquid-Liquid Phase Separation, LLPS)是指在细胞内某些生物大分子(如蛋白质和RNA)通过相互作用,形成具有不同组分和性质的相分离液滴 [1]。
Mutual promotion of co-condensation of KRAS G ... - Oxford …
2023年10月28日 · In this work, we investigated the LLPS of HMGB1 and the KRAS promoter DNA (22R) in its GQ structure (termed GQ KRAS). Interestingly, the result reveals that …
Liquid-liquid phase separation: Fundamental physical principles ...
2023年12月1日 · This review offers a concise overview of LLPS in soft matter, emphasizing its relevance in soft material engineering. We delve into fundamental mechanisms, focusing on …
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