2023年6月1日 · Our data suggest that in LLV individuals, at least from an autocrine perspective, CD4 + T cells differentiate towards a Th1-like phenotype not only by upregulating Th1 lineage …

2024年8月19日 · LLV between 50 and 200 copies/mL leads to reduced cytotoxic activity and T-cell dysfunction that could affect cytokine production, being unable to control and eliminate …

2023年3月11日 · Our results show that Th1 signature genes, including TBX21, NOTCH3 and IL12RB2, were upregulated in CD4 + T cells in LLV compared to VS (Fig. 2 B, E). Although …

Characterization of DEGs in key overlapping pathways showed that CD4 + T cells in LLV expressed higher levels of Th1 signature transcription factors (TBX21), toll-like receptors (TLR …

辅助T细胞（Th1）是一类能够发挥重要作用的免疫细胞。它们有助于身体对病菌、细胞和组织的抵御能力，因此对健康至关重要。Th1细胞主要通过发挥它们的细胞因子作用来支持机体的免疫 …

Around 10% of people with HIV (PWH) show a low-level viremia (LLV) under antiretroviral therapy (ART), but its clinical relevance is still unclear especially in the era of integrase strand transfer …

Characterization of DEGs in key overlapping pathways showed that CD4 + T cells in LLV expressed higher levels of Th1 signature transcription factors (TBX21), toll-like receptors (TLR …

研究表明，IL-12通过 Stat4 和激活一种独特的TH1转录因子——T细胞中表达的T-box（ T-bet ）来驱动TH1细胞分化，T-box上调IFN-γ并下调IL-4和IL-5的表达。 相反，IL-4通过Stat6诱导TH2 …

2015年9月5日 · We found that CD4 T cells enriched for a Th1/17 polarization had elevated susceptibilities to HIV-1 infection in ex vivo assays, harbored high levels of HIV-1 DNA in …

流式细胞术 是检测Th1/Th2细胞的一种常见技术，通过流式细胞仪可以分析T细胞表面标记物、细胞内细胞因子及转录因子的表达，以此来区分不同的T细胞亚群。