2019美国癌症研究协会（AACR）年会—新药前瞻 - 知乎
大型多功能肽酶7（LMP7）也称为β5i或PSMB8，是免疫蛋白酶体（immunoproteasome）中一种类似糜蛋白酶的蛋白水解亚基，能够降解 泛素化 蛋白并产生呈递给 MHCⅠ 的多肽。
Immunoproteasome subunit LMP7 Deficiency Improves …
2015年10月30日 · Low-molecular mass protein-7 (LMP7) is a proteolytic subunit of the immunoproteasome that shapes the repertoire of antigenic peptides on major histocompatibility...
The Immunoproteasome Subunits LMP2, LMP7 and MECL-1 …
2021年4月21日 · In summary we provide evidence for a critical role of the IP subunits β1i/LMP2, β2i/MECL-1 and β5i/LMP7 for the control of cerebral Toxoplasma gondii infection and …
PSMB8/LMP7 (1A5) Mouse mAb #13726 - Cell Signaling …
PSMB8/LMP7 (1A5) Mouse mAb recognizes endogenous levels of total PSMB8/LMP7 protein. This antibody recognizes both 28 kDa precursor and 23 kDa mature forms of PSMB8/LMP7 …
Immunoproteasome subunit LMP7 deficiency and inhibition …
2012年10月15日 · LMP7 governs Th cell lineage determination by affecting the balance of receptor proximal signals during differentiation. These data render LMP7 a promising drug …
免疫蛋白酶体选择性抑制剂的抗肿瘤活性。,Blood - X-MOL
2007年11月16日 · 在造血细胞中占主导地位的免疫蛋白酶体包含独特的活性位点亚基 LMP7、LMP2 和 MECL1，分别具有胰凝乳蛋白酶样、半胱天冬酶样和胰蛋白酶样活性。 蛋白酶体抑制 …
Inhibition and deficiency of the immunoproteasome subunit LMP7 …
Since the immunoproteasome promotes Th1 and Th17 differentiation and pro-inflammatory cytokine production, we investigated here whether deficiency or inhibition of the …
Co-inhibition of immunoproteasome subunits LMP2 and LMP7 is ... - PubMed
Here, we show that PRN1126, developed as an exclusively LMP7-specific inhibitor, has limited effects on IL-6 secretion, experimental colitis, and experimental autoimmune …
Co-Inhibition of the Immunoproteasome Subunits LMP2 and LMP7 ...
2021年1月20日 · We found that the expression of the immunoproteasome catalytic subunit, large multifunctional protease 2 (LMP2), was significantly upregulated in peripheral blood …
MHC-encoded proteasome subunits LMP2 and LMP7 are not …
1994年2月1日 · LMP2 and LMP7 are subunits of a subset of proteasomes, large molecular assemblies with multi-proteolytic activities believed to degrade damaged and unwanted …