This topic will review the general principles underlying the therapeutic use of unfractionated and LMW heparins including dosing, monitoring, and reversal of anticoagulation, as well as danaparoid (not available in the United States).

Learn about the dosing amounts available for two common Low-Molecular-Weight Heparin (LMWH) medications -- Enoxaparin and Dalteparin -- from the Anticoagulation Clinic at UC San Diego Health.

2023年8月4日 · Compared to heparin, LMWHs have a longer half-life, so dosing is more predictable and can be less frequent, most commonly once per day. However, patients with a high body weight will need higher doses and sometimes two doses daily, depending on local administration policy.

2018年6月28日 · Low molecular weight heparin (LMWH) is an anticoagulant that inhibits factor Xa and IIa (thrombin) activity in the coagulation pathway. Unlike unfractionated heparin (UFH), it does not require frequent monitoring for efficacy and is 10 times less likely to cause heparin induced thrombocytopenia (HIT).[1] .

It is our practice to reduce full dose enoxaparin by one level (from 1mg/kg SQ q12h to 0.85mg/kg SQ q12h, or from 0.85mg/kg SQ q12h to 1mg/kg SQ q24h) in patients on concurrent CNI therapy. Routine monitoring of Anti-Xa levels is not recommended as there is …

maintenance dosing based on GFR:-> > 60mL/min – 1mg/kg Q12 hourly or 1.5mg/kg Q24 hourly-> 30-60mL/min – 0.8mg/kg Q12 hourly-> < 30mL/min – 0.66mg/kg Q12 hourly; can measure anti-Xa levels in therapeutic anti-coagulation (renal impairment + very low or very high BMI, pregnancy) ANTI-Xa MONITORING. establish steady state (48 hours of dosing)

Use TBW to calculate dosing. UFH preferred, or: .

Low molecular weight heparin (LMWH) provides effective, rapid anticoagulation and is used in the acute management of venous thromboembolic disease (VTE), often in conjunction with warfarin until INR target is reached. Those who are not suitable for oral anticoagulation may require extended LMWH treatment.

Doses for unfractionated heparin and low molecular weight heparin from UC San Diego Health's anticoagulation experts.

2024年7月16日 · Low molecular weight heparin (LMWH) is a class of medication used as an anticoagulant in diseases that feature thrombosis, as well as for prophylaxis in situations that lead to a high risk of thrombosis.