高糖高脂诱导的L02细胞（人源正常肝细胞）糖尿病肝损伤模型的 …
2023年9月14日 · 2型糖尿病（Type 2 Diabetes Mellitus,T2DM），是与代谢紊乱相关的慢性疾病，具有持续高血糖和脂质代谢异常的特点，已然成为一种严重的全球健康负担。 T2DM还可以 …
YAP1 protects against septic liver injury via ferroptosis resistance
2022年10月1日 · Consistently, YAP1 deficiency aggravated LO2 cells ferroptosis, but YAP1 overexpression alleviated LPS-induced LO2 ferritinophagy, as evidenced by reduced …
探究光动力治疗下细胞线粒体微环境 - X-MOL科学知识平台
PDT已用于临床癌症治疗，它是由光敏剂在特定波长光照射下引发光化学反应产生活性氧物质（Reactive oxygen species, 简称ROS）杀伤肿瘤的治疗方法。 徐抒平教授课题组之前采 …
Bdh1 overexpression ameliorates hepatic injury by activation of …
2022年2月3日 · Bdh1 knockdown led to ROS overproduction and ROS-induced inflammation and apoptosis in LO2 cells, while Bdh1 overexpression protected LO2 cells from lipotoxicity by …
Hepatoprotective effect of cyanidin-3- - ScienceDirect
2023年8月1日 · C3G–LA up-regulated the expression levels of Nrf2 and the downstream expression levels of NQO1 and HO-1 in H 2 O 2-stressed LO2 cells, inhibited the excessive …
棕榈酸PA、油酸OA诱导肝细胞系（HepG2、LO2细胞）建立代谢 …
HepG2细胞和LO2细胞均使用含10%胎牛血清的DMEM培养基，置于37℃、5%的CO2培养箱中培养，待细胞汇合度达到70%~80%时，用0.25%胰酶-EDTA消化细胞，按1：3传代。 取对数生 …
Cholesterol-induced leucine aminopeptidase 3 (LAP3) …
We compared the reactive oxygen species (ROS) levels between CHO-treated cells and control groups in LO2 cells by flow cytometry. The results showed that CHO-treated LO2 cells …
Crocetin Protected Human Hepatocyte LO2 Cell From TGF-β …
These results indicated that crocetin prevented LO2 cells from TGF-β-induced injury by regulating ROS, SOD, MDA, and GSH levels, as well as COL1A1, TGF-β, α-SMA, and NDRG2 levels. …
Naringenin Induces HepG2 Cell Apoptosis via ROS-Mediated JAK …
2023年6月1日 · ROS not only stimulate caspase-9 and further activate caspase-3, which leads to the fragmentation of PARP, but also decrease the expression of the JAK-2 protein and STAT …
纳米人 - m.nanoer.net
吉林大学徐抒平教授通过荧光成像技术监测了经过不同剂量的光动力治疗 (PDT)后的线粒体微环境，包括线粒体膜电位 (MMP)和活性氧 (ROS)，并利用三种细胞系 (HepG2、MCF-7和LO2)进 …