LOX-1，一种从内皮细胞中识别出的氧化型低密度脂蛋白受体：对内皮功能障碍和动脉粥样硬化的影响。 凝集素样氧化低密度脂蛋白（LDL）受体1（LOX-1）最初被确定为内皮细胞中氧化LDL（OxLDL）的主要受体。 还观察到其在巨噬细胞和平滑肌细胞中的诱导表达。 LOX-1是II型膜蛋白，在细胞外C端具有典型的C型凝集素结构。 它可以被细胞外近膜区域的未知蛋白酶切割，从而释放出可溶的LOX-1形式。 LOX-1的胞外域通过N-联糖基化进行翻译后修饰。 诱变研究表 …

2023年6月25日 · 血管内皮细胞表面高表达凝集素样氧化低密度脂蛋白 (LDL)受体-1 (LOX-1)，能够结合并将氧化低密度脂蛋白 (oxLDL)转移到动脉粥样硬化中被巨噬细胞浸润的血管内膜。 巨噬细胞通过几种清道夫受体 (SR)如SR- A1、CD36和LOX…

2020年11月12日 · Lox-1 (lectin-like oxLDL [oxidized low-density lipoprotein] receptor 1) is a transmembrane protein expressed in endothelial cells, platelets, macrophages, smooth muscle cells, and cardiomyocytes. Activation of Lox-1 by oxLDL is implicated in the progression of atherosclerosis, myocardial fibrosis, and endothelial dysfunction.

Lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1) was initially identified as the major receptor for oxidized LDL (OxLDL) in endothelial cells. Its inducible expression in macrophages and smooth muscle cell was also observed. LOX-1 is a Type II membrane protein with a typical C-t …

LOX-1 is the main receptor for oxidized low-density lipoproteins (ox-LDL). The LDL comes from food intake and circulates through the bloodstream. LOX-1 belongs to scavenger receptors (SR), which are associated with various cardiovascular diseases.

Among SRs, LOX-1, a member of the class E SR family, plays a critical role in atherosclerosis. LOX-1 is a 50-kDA transmembrane glycoprotein that was initially identified in bovine aortic endothelial cells, where it acted as an important receptor for the binding, internalization and degradation of ox-LDL . It has a cytoplasmic, transmembrane ...

2019年7月11日 · LOX-1 is a transmembrane glycoprotein that binds to and internalizes ox-LDL. This interaction results in variable downstream effects based on the cell type. In endothelial cells, there is an increased expression of cellular adhesion molecules, resulting in the increased attachment and migration of inflammatory cells to intima, followed by their ...

2002年7月1日 · Lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1) was initially identified as the major receptor for oxidized LDL (OxLDL) in endothelial cells. Its inducible expression in macrophages and smooth muscle cell was also observed.

Lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) has been proven to be significantly important in the development and progression of atherosclerosis. Accumulating evidence has emerged to support the diversity of extracellular legends for LOX-1 to induce intracellular effects.

LOX-1 is a unique membrane receptor in terms that it seems to elicit biological functions via diverse mechanisms; LOX-1 uptakes oxLDL as an endocytotic receptor, tethers leukocytes and platelets as an adhesion molecule, and immediately generates ROS through the activation of intercellular molecules.