Lysyl oxidase homolog 1, also known as LOXL1, is an enzyme which in humans is encoded by the LOXL1 gene. [4][5] This gene encodes a member of the lysyl oxidase gene family.

2024年12月25日 · LOXL1 (Lysyl Oxidase Like 1) is a Protein Coding gene. Diseases associated with LOXL1 include Exfoliation Syndrome and Intraocular Pressure Quantitative Trait Locus. Among its related pathways are Collagen chain trimerization and Elastic fibre formation.

该家族的原型成员对结缔组织的生物发生至关重要，编码细胞外铜依赖性胺氧化酶，催化胶原蛋白和弹性蛋白交联形成的第一步。 编码的前原蛋白经过蛋白水解处理以产生成熟酶。 C 末端高度保守的氨基酸序列似乎足以维持胺氧化酶活性，表明每个家族成员都可能保留此功能。 N 末端的保守性很差，可能在发育调节、衰老、肿瘤抑制、细胞生长控制和趋化性方面赋予每个家族成员额外的作用。 该基因的突变与剥脱综合征有关。 [RefSeq 提供，2016 年 1 月] This gene encodes a …

2020年4月1日 · Lysyl Oxidase Like 1 (LOXL1) is a gene that encodes for the LOXL1 enzyme. This enzyme is required for elastin biogenesis and collagen cross-linking, polymerising tropoelastin monomers into elastin polymers. Its main role is in elastin homeostasis and matrix remodelling during injury, fibrosis and cancer development.

研究表明， 赖氨酰氧化酶 1（Loxl1）表达缺失会导致骨盆器官脱垂和剥脱综合征性青光眼，此外， Loxl1缺失还促进癌症等疾病发病机制。然而，其生物学功能效应与不同器官的临床相关性一直未得到深入研究。

2020年5月18日 · LOXL1 was found to exhibit antiapoptotic activity by interacting with multiple antiapoptosis modulators, especially BAG family molecular chaperone regulator 2 (BAG2). LOXL1-D515 interacted with...

Findings indicate that lysyl oxidase (LOX) could be a potential therapeutic target for early recurrence of hepatocellular carcinoma (HCC). LOXL1 variants that contribute to exfoliative glaucoma demonstrate various differences and are also common in normal population.

Chromosome 15: 74,218,330-74,244,478 forward strand. This gene has 5 transcripts (splice variants), 12 paralogues and is associated with 2 phenotypes. Sorry, the page request "/Homo_sapiens/Component/Gene/Summary/gene_summary?g=ENSG00000129038;r=15:74218330-74244478;db=core;time=1740574870204.204" failed to load.

2024年1月25日 · Molecular and immunological characterization found that LOXL1 might mediate epithelial-mesenchymal transition (EMT) process and immunosuppressive phenotypes of CRC. Functional study found that LOXL1 enhanced tumor cell proliferation, migration and invasion.

赖氨酰氧化酶样蛋白1(lysyl oxidase like 1，LOXL1)作为一种分泌型的铜依赖性胺氧化酶，在多种类型细胞中广泛存在。LOXL1可以维持弹性蛋白的稳态，参与细胞外基质的重塑，在机体发育、组织损伤、纤维化疾病和癌症的发展过程中发挥重要作用。