There was no further increase in tissue factor expression in the sodding cells with stimulation with lipopolysaccharide (LPS); however, purified MEC expressed significantly more tissue factor after exposure to LPS (1247 +/- 356 pg/mL, P < 0.05).

2011年9月27日 · The structure of lipopolysaccharide (LPS) expressed by non-typeable Haemophilus influenzae (NTHi) strains 1008 and 1247 has been investigated by mass spectrometry and NMR analyses on O-deacylated LPS and core oligosaccharide material.

2011年9月27日 · The structure of lipopolysaccharide (LPS) expressed by non-typeable Haemophilus influenzae (NTHi) strains 1008 and 1247 has been investigated by mass spectrometry and NMR analyses on O-deacylated LPS and core oligosaccharide material. Both strains express the conserved triheptosyl inner core, [l-α-d …

Here, we identified extended synaptotagmin 1 (E-Syt1), an endoplasmic reticulum protein, as a key regulator of Casp-11 oligomerization and activation. Macrophages lacking E-Syt1 exhibited reduced production of interleukin-1b (IL-1 ) and impaired pyroptosis upon cytosolic. lipopolysaccharide (LPS) delivery and cytosol-invasive bacterial infection.

2009年3月16日 · Based on the Lex2B sequence data and our knowledge of the LPS structures of the strains, we chose six NTHi strains, strains 432, 1008, 1124, 1247, 1292, and 2019, for further study. Lex2B from strains 432, 1124, and 2019 is predicted to add a galactose, and LPS structural studies have confirmed that a galactose residue is indeed found as HexII ...

结论 在急性肺炎模型中,microRNA-1247 是通过趋化因子配体CCR16 抑制因LPS 诱导的急性肺炎而导致的各种细胞因子及蛋白表达升高?

[摘要]: 目的 观察原花青素B1（PB1）对脂多糖（LPS）诱导的小鼠巨噬细胞RAW264.7损伤的保护作用，探讨其可能的作用机制。 方法 体外培养的处于对数生长期的小鼠巨噬细胞RAW264.7分为对照组（细胞不进行处理）、LPS组（细胞给予2 mg·L -1 LPS）、PB1组（细胞给予10 μmol·L -1 PB1）和PB1+LPS组（细胞给予2 mg·L -1 LPS+10 μmol·L -1 PB1）。 显微镜下观察各组细胞形态表现，流式细胞术检测各组细胞中活性氧（ROS）水平、细胞凋亡率和细胞表面膜分 …

2021年6月1日 · LPS can increase the expression of miRNA-150 and miR-127, and negatively regulate the target gene PDCD4 to promote inflammation. miR-141 and miR-200c can attenuate the activation of the NF-κB signaling pathway. let-7b targets TLR4 to suppress inflammation. miR-1247-3p and miR-195 are involved in the inflammatory response through the MAPK pathway.

目的 探究微小RNA-1247-3p(miR-1247-3p)对脂多糖(LPS)诱导的肺泡上皮细胞增殖、凋亡的影响.方法 将人肺泡上皮A549细胞分为对照组(常规培养),LPS 5 mg/L、LPS 10 mg/L和LPS 15 mg/L组(5 mg/L、10 mg/L、15 mg/L LPS诱导24 h),荧光定量PCR(qPCR)检测miR-1247-3p的表达量;后续将对数期A549细胞随机 ...

2023年3月17日 · 本实验结果显示，薄荷脑可降低LPS 诱导的AT-Ⅱ细胞中miR-1247-3p 表达水平；而miR-1247-3p 高表达逆转了薄荷脑对LPS 诱导的AT-Ⅱ细胞凋亡、炎症反应，表明薄荷脑可调控miR-1247-3p表达。