
Negative regulation of NF-κB p65 activity by serine 536 ... - Science
2016年8月23日 · Ser 536 (S536) of the p65 subunit represents the site with the most potent inducible phosphorylation in response to inflammatory stimuli (9), and it is highly conserved among different species (10), indicating a potential role …
IKKβ Plays an Essential Role in the Phosphorylation of RelA/p65 on ...
2003年6月1日 · Using IKKα −/− and IKKβ −/− mouse embryonic fibroblasts (MEFs), we found that IKKβ was essential for the LPS-induced p65 phosphorylation on serine 536, whereas loss of IKKα only partially impaired LPS-induced p65 phosphorylation. In contrast, although phosphorylation of p65 on serine 536 was decreased, IKKβ was not essential for ...
Negative regulation of NF-κB p65 activity by serine 536 ... - PubMed
2016年8月23日 · We investigated the contribution of the phosphorylation of the NF-κB subunit p65 at the IKK phosphorylation site serine 536 (Ser(536)) in humans, which is thought to be required for the activation and nuclear translocation of NF-κB.
Stepwise phosphorylation of p65 promotes NF-κB activation …
2016年5月25日 · Vav1 controls downstream p65 phosphorylation and NF-κB activation. Synergistic signalling is defective in X-linked lymphoproliferative disease (XLP1) NK cells entailing 2B4 dysfunction and required...
Integrin-linked Kinase Modulates Lipopolysaccharide- and …
2014年10月3日 · Rather, ILK modulates LPS-stimulated NF-κB transcription activity through p65 phosphorylation at Ser-536 and is required for LPS-induced transactivation of p65 through Ser-536. Using an in vitro model of Helicobacter pylori infection, we show that ILK is required for H. pylori -induced p65 Ser-536 phosphorylation and TNF-α secretion.
Oxyimperatorin attenuates LPS-induced microglial activation
2024年4月1日 · Interesting, co-treatment with OIMP could significantly reduce the phosphorylation of NF-κB p65 at serine 536 (S536) in LPS-stimulated BV-2 microglia cells (Fig. 5 B). Furthermore, we tested the effects of OIMP on LPS-stimulated NF-κB p65 nuclear translocation in BV-2 cells.
Bruton's Tyrosine Kinase Is Involved in p65-mediated …
2005年6月24日 · LPS induced a strong increase in p65 phosphorylation on serine 536 in multiple cell types tested, including HEK293-TLR4 and U373 cells (Fig. 3a, left-and right-hand panels, respectively). A response in both cell types from 15 min was evident.
Ser536 (S536) of the p65 subunit represents the site with the most potent inducible phosphorylation in response to inflammatory stimuli (9), and it is highly con-served among different species (10), indicating a potential role in the reg-ulation of inducible NF-kB activity.
LPS-induced serine 536 phosphorylation of NFκB p65 in
After 15 min of LPS stimulation, the intensity of serine 536 phosphorylated p65 staining increased dramatically in WT but not in NKLAM-KO macrophages (Fig. 7A). In addition, this increase in...
Negative regulation of NF-κB p65 activity by serine 536 …
Ser 536 (S536) of the p65 subunit represents the site with the most potent inducible phosphorylation in response to inflammatory stimuli (9), and it is highly conserved among different species (10), indicating a potential role in the regulation of inducible NF-κB activity.