LPS-induced mortality in CD11c-Cre A20 (fl/fl) mice was characterized by increased serum levels of IL-2, IL-10, IL-12, IFN-γ, and TNF. Upon LPS stimulation, the activation of NF-κB and ERK …

2016年8月22日 · 结论：a20能够抑制肺泡巨噬细胞nfκb活性及tnfα、il1β分泌，进而抑制肺泡巨噬细胞炎症反应活性〖bp（〗，由此推测能够减轻急性呼吸窘迫综合征（ards）炎症反应。

2017年7月20日 · The A20 group exhibited significantly up-regulated A20 expression compared to the NS, LPS, and LPS-C1 groups, and down-regulated NF-κB p65 and NF-κB p-P65 …

The ubiquitin-editing enzyme A20 is known to inhibit the NF-κB transcription factor in the Toll-like receptor (TLR) pathways, thereby negatively regulating inflammation. However, its role in the …

锌指蛋白A20是一种内源性保护蛋白，其可通过A20自身的去K-63泛素酶及K-48泛素酶对同一底物实行去泛素化及泛素化实现负反馈地抑制NF-κB炎症信号通路的传导，在炎症疾病领域受到密 …

2019年4月15日 · Our experimental results showed that, in LPS-treated BV2 cells, zinc supplement induced expression of A20 and augmented its inhibitory effects on NF-κB …

Nrf2 转录因子通过上调抗氧化基因表达和 TNFα 诱导的蛋白 3（TNFAIP3，又名 A20）去泛素酶通过控制 NF-kB 信号抑制组织炎症来抑制细胞应激和控制炎症。 在这里，我们报告 Nrf2 是炎症 …

2014年12月4日 · Here, we demonstrate that upon injection of low-dose LPS, mice with DC-specific A20 deletion (CD11c-Cre A20 fl/fl) died within 6 h, whereas A20 fl/fl controls survived. …

2009年7月15日 · The state of tolerance, which lasts 20-26 h, temporally coincides with LPS-induced expression of the anti-inflammatory ubiquitin-editing enzyme A20. Small interfering …

2011年2月4日 · Silencing of A20 restored TRAF6 expression and NF-κB activation and resulted in increased bone resorption in LPS-treated cultures. A20 appeared important in the control of …