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2017年8月9日 · To understand the structural basis of how ABC transporter LptB 2 FG extracts and transports LPS, we have solved the crystal structure of the LptB 2 FG complex from …

2019年11月1日 · The LptB 2 FG ABC transporter acts like the spring-loaded platform of the PEZ dispenser and provides a constant pressure to LPS stream by loading new LPS molecules into …

2017年4月10日 · After biosynthesis, bacterial lipopolysaccharides (LPS) are transiently anchored to the outer leaflet of the inner membrane (IM). The ATP-binding cassette (ABC) transporter …

2017年9月6日 · Our study uncovers the structural basis for LPS recognition, delineates the conformational transitions of MsbA to flip LPS, and paves the way for structural …

The LptB 2 FG complex is an ABC transporter that hydrolyzes ATP to extract LPS from the inner membrane for transport to the outer membrane. Here, we extracted LptB 2 FG directly from …

Gram-negative bacteria protect themselves from chemical stressors by incorporating hydrophobic lipopolysaccharide (LPS) into their outer membranes. The LPS coating acts as a physical …

2012年7月15日 · The Lpt pathway for transport of LPS to the bacterial cell surface. Export of LPS across the IM and insertion of the molecule into the outer leaflet of the OM involves at least …

The ATP-binding cassette (ABC) transporter LptB 2 FG extracts LPS molecules from the IM and transports them to the outer membrane. Here we report the crystal structure of nucleotide-free …

2020年8月1日 · Lipopolysaccharide (LPS) is the primary lipid component in the outermost membrane leaflet of most Gram-negative bacteria, and plays critical roles in cell envelope …