2024年10月3日 · Specifically, we show that the amine headgroups in ionizable lipids drive LNP immunogenicity by binding to Toll-like receptor 4 and CD1d and by promoting lipid-raft formation.

Lipopolysaccharides (LPS) are endotoxins, hazardous and toxic inflammatory stimulators released from the outer membrane of Gram-negative bacteria, and are the major cause of septic shock giving rise to millions of fatal illnesses worldwide. There is an urgent need to identify and detect these molecules selectively and rapidly.

心脏功能障碍 (心脏炎症) 是脂多糖 (lps) 诱导脓毒症的常见并发症，其原因是严重的炎症反应。lps 还可引起心脏收缩功能恶化，心脏脂质过氧化增加，导致心脏功能障碍。

2023年4月17日 · Lipopolysaccharides (LPS) are important outer membrane components of gram-negative bacteria. They are large amphipathic glycoconjugates that typically consist of a lipid domain (hydrophobic) attached to a core oligosaccharide and a distal polysaccharide. These molecules are also known as lipoglycans due to the presence of lipid and sugar molecules.

2024年1月3日 · Here, using structural, biochemical and genetic approaches, we show that these antibiotics trap a substrate-bound conformation of the LPS transporter that stalls this machine. The inhibitors...

脂多糖 （Lipopolysaccharide, LPS）是革兰氏阴性细菌外膜的重要成分，对细菌的生存和致病性具有重要影响。LPS位于细菌外膜的外层，在无荚膜菌株中直接暴露在细胞表面。

2023年3月1日 · The abundance of LPS in the outer membrane of most gram-negative bacteria is central to its structural integrity and protection against xenobiotics, detergents and bile acids found in harsh environments. Thus, LPS biosynthesis and transport machinery are attractive therapeutic targets in most gram-negative bacteria.

2022年2月1日 · Lipopolysaccharides (LPS) are the main components of the external leaflet of the Gram-negative outer membrane and consist of three different moieties: lipid A, core oligosaccharide, and O-polysaccharide.

Lipopolysaccharide (LPS) is a fundamental tripartite glycolipid found on the surface of nearly all Gram-negative bacteria. It acts as a protective shield for the bacterial cell and is a potent agonist of the innate immune system.

2023年12月18日 · lps由一个多糖区域组成，该区域由被称为脂质a的特定糖脂部分锚定在细菌外膜上。 脂质A是一种与羟基脂肪酸相连的葡萄糖胺双糖，羟基脂肪酸进一步被非羟基脂肪酸取代。