2023年4月17日 · LPS is a serologically reactive bacterial toxin, and as little as 1 to 2 mg entered intravenously can be lethal. LPS can enter the bloodstream through intestinal absorption of the LPS produced by gut bacteria. The LPS does not damage the gut epithelium of the luminal side.

Lipopolysaccharides (LPS) are large molecules consisting of three parts: an outer core polysaccharide termed the O- antigen, an inner core oligosaccharide and Lipid A (from which toxicity is largely derived), all covalently linked.

Lipopolysaccharide (LPS) is a cell-wall immunostimulatory endotoxin component of Gram-negative bacteria. A growing body of evidence reveals that alterations in the bacterial composition of the intestinal microbiota (gut dysbiosis) disrupt …

LPS can also play a crucial role in bacteria-host interactions by modulating responses by the host immune system. Three main areas of LPS biology are covered in this review.

2015年11月25日 · LPS-induced disruption appears is to be dependent on COX but not on oxidative stress. Based on in vivo and in vitro measures of neuroinflammation, it appears that astrocytes, microglia/macrophages, and pericytes play little …

2022年11月1日 · We overview the current understanding of the relationship between LPS structure and toxicity, conditions in which the supramolecular arrangement of LPS can be altered, the hypothesised mechanisms of LER, and discuss the possible risk of masked LPS remaining biologically toxic upon administration to patients.

The use of LPS as a strong pro-inflammatory agent is a well-known model of inflammation applied in both in vivo and in vitro studies. This review offers a summary of the pathogenesis associated with LPS exposure, especially in the field of neuroinflammation. Moreover, we analyzed different in vivo LPS models utilized in the area of neuroscience.

2019年5月29日 · To alter properties of the outer membrane or evade the host immune response, Gram-negative bacteria chemically modify LPS in a wide variety of ways. Here, we review key features and physiological...

2024年3月16日 · Can targeting LPS delivery systems be a viable therapeutic strategy for modulating inflammatory responses and improving outcomes in patients with sepsis? Translating findings from LPS delivery studies into clinical applications requires a comprehensive understanding of the complex interactions between LPS and the host immune system in the ...

2010年4月1日 · LPS or lipid A can cause diseases such as septic shock, multiple organ dysfunction and failure. Understanding the biochemistry of lipid A modifications and their impact on pathogenesis could lead to novel treatment options for these diseases.