Fibroblastic reticular cell-derived exosomes are a promising ...
2024年3月1日 · RNA-Seq analysis of FRC-Exo-treated primary kidney tubular cells (PKTCs) revealed that FRC-Exos influenced PKTC fate in the presence of lipopolysaccharide (LPS). …
Fibroblastic reticular cell-derived exosomes are a promising ...
FRC-Exos promoted kinase PINK1-dependent mitophagy and inhibited NLRP3 inflammasome activation in LPS-stimulated PKTCs. To dissect the mechanism underlying the protective role …
2023年12月30日 · In this study, we demonstrated that FRC-Exos improved kidney function in S-AKI. FRC-Exos, which are rich in CD5L, promoted PINK-Parkin–mediated mitophagy in …
The CLEC-2–podoplanin axis controls the contractility of ... - Nature
2014年10月27日 · Fibroblastic reticular cells (FRCs) are LN-resident mesenchymal cells that secrete and remodel the extracellular matrix to create a dense reticular network....
成纤维细胞网状细胞衍生的外泌体是治疗脓毒症急性肾损伤的一种 …
FRC-Exos 在 LPS 刺激的 PKTC 中促进激酶 PINK1 依赖性线粒体自噬并抑制 NLRP3 炎性体激活。为了剖析 Exos 在 S-AKI 中的保护作用背后的机制，我们通过质谱法检查了 Exos 内的蛋白 …
JCI - TLR9 signaling in fibroblastic reticular cells regulates ...
2019年8月5日 · Fibroblastic reticular cells (FRCs), a subpopulation of stromal cells in lymphoid organs and fat-associated lymphoid clusters (FALCs) in adipose tissue, play immune …
【文献解读】本会会员彭志勇教授团队《Kidney Int》发文，揭示改良的FRC …
2024年2月22日 · 淋巴结中富含成纤维网状细胞（FRC），其与免疫细胞存在着广泛的正向相互作用，可促进淋巴管的生成和T细胞的存活。 最近有研究发现 FRC 移植在小鼠脓毒症中显示出 …
纤维网状细胞通过促进线粒体凋亡对脓毒症急性肾损伤改善作用的 …
目的 探讨纤维网状细胞 (FRC)通过促进线粒体凋亡对脓毒症急性肾损伤 (AKI)的改善作用.方法 取10～12周龄的C57BL/6雄性小鼠分别进行小鼠原代肾小管上皮细胞 (TECs)及小鼠肠系膜脂肪 …
Lymph node fibroblastic reticular cell transplants show robust ...
We describe a population of immune-specialized myofibroblasts derived from lymph node tissue, termed fibroblastic reticular cells (FRCs). Because FRCs have an immunoregulatory function …
Role of TLR In The Cell Fate Decision of Fibroblastic Reticular Cells
2023年5月1日 · We have shown that Fibroblastic Reticular Cells (FRC)-based therapy improves outcome in a mouse polymicrobial sepsis model. Modulating TLR4 and TLR9 signaling in FRC …