2022年1月12日 · We show here that bacterial lipopolysaccharide (LPS) induces oncostatin M (OSM) and that airway biopsies from patients with severe asthma present with an OSM-driven transcriptional profile. This profile correlates with activation of …

2022年4月20日 · 我们在这项新的研究中发现，细菌LPS诱导OSM表达，重症哮喘患者的气道活组织呈现出OSM驱动的转录特征。 Headland补充说，“这种情况与炎症途径和粘液生成途径的激活相关。 ”她指出，使用“天然人类肺组织或人类上皮细胞和间质细胞，我们证实OSM对于驱动暴露于LPS后观察到的重症哮喘的病理生理特征是必要和充分的”。 虽然这一新的分析帮助科学家们对严重的细菌相关哮喘的潜在驱动因素有了更深刻的理解，但是他们的研究也提示着有朝一日一种 …

2022年2月2日 · An anti-OSM antibody reduces acute exacerbations in a mouse model. Bacteria contain lipopolysaccharide (LPS), which binds to Toll-like receptor 4 (TLR4) and activates downstream signalling.

2022年1月15日 · 为了明确细菌触发哮喘的相关机制，研究人员从细菌的主要分泌物脂多糖（lps）入手寻找答案。 LPS所诱导分泌的促炎分子主要有IL-α、IL-β、TNF-α、IL-8等等，除此之外，还有一种细胞因子OSM。

2013年4月1日 · IL-27 together with lipopolysaccharide (LPS) induced morphological change into more spread and elongated cells and synergistically enhanced NO production. The combined stimulation also enhanced iNOS mRNA expression and the NO production was abrogated by an iNOS inhibitor, NG-monomethyl l -arginine.

Our findings that LPS and OSM synergized to enhance VEGF levels in the supernatants of HAoAFs and HAoSMCs suggest another mechanism by which OSM or LPS could impact inflammation and remodelling in the vascular wall by modulating local levels of VEGF.

1999年2月15日 · Oncostatin M (OSM) is an interleukin-6 (IL-6) family cytokine known in particular to induce the synthesis of acute-phase proteins by hepatocytes. Because human polymorphonuclear neutrophils (PMN) can secrete numerous cytokines, the potential production of OSM by PMN was investigated.

2022年1月12日 · We show here that bacterial lipopolysaccharide (LPS) induces oncostatin M (OSM) and that airway biopsies from patients with severe asthma present with an OSM-driven tran-scriptional profile. This profile correlates with activation of …

ELISAs performed on cell supernatants showed that stimulation with OSM alone caused increased MCP-1, IL-6, and VEGF levels. When combined, LPS and OSM synergized to increase MCP-1, IL-6, VEGF protein, and mRNA expression as assessed by qRT-PCR, in both HAoAFs and HAoSMCs, while LPS-induced IL-8 levels were reduced.

2021年6月29日 · 7.针对现有技术中存在的技术问题，本发明提供了一种抑瘤素m (osm)联合脂多糖 (lps)诱导人鼻粘膜上皮细胞炎症模型、制法以及应用，其是先使用osm刺激鼻腔黏膜上皮细胞hnepc，再用lps处理细胞，从而模拟细胞受到变应原感染后发生的炎症反应。 8.所述的模型对鼻腔炎症反应还原性高，更能完善真实地评价鼻腔类产品的抗炎效果及对慢性鼻炎有治疗或症状缓解的活性物筛选实验及机制研究，且解决了单一脂多糖诱导炎症模型的不稳定性问题。 12.更换所 …