To mimic the entrance of bacterial-derived compounds into the host, an endotoxemia model has been adopted in which lipopolysaccharide (LPS), a component of the outer cell wall of Gram-negative bacteria, were injected into mice. In this study, a sublethal dose of LPS was intraperitoneally injected and the mice were subsequently monitored for 8 h ...

5 天之前 · Injection of such low doses of LPS achieves serum LPS levels similar to those of human patients (2.5 μg LPS i.p. in mice yields ≈2 ng ml-1 after 1 h and ≈0.4 ng ml-1 24 h) 53.

2020年8月1日 · We have compared inflammation-induced sickness behavior in rodents and humans. LPS-induced signs of sickness in rodents and humans appear to follow similar patterns. Depressive- and anxiety-like behaviors cannot be compared in a straightforward manner between rodents and humans.

2020年2月4日 · This review describes the molecular mechanisms that contribute to lung injury in rodent models of LPS-induced organ injury mimicking either pulmonary or extra-pulmonary ARDS. Pathways of LPS-induced lung injury are not only affected by the type of the primary insult and the presence of additional stimuli but also by time.

2019年4月8日 · Lipopolysaccharide (LPS; a cell-wall immunostimulatory component of gram-negative bacteria) was first identified as a Toll-like receptor 4 (TLR-4) ligand 17.

Lipopolysaccharide (LPS), a component of gram-negative bacteria that reside in the intestines, can be released into circulation and stimulate the immune system, upregulating bone resorption. Exogenous LPS is used in rodent models to study the effect of systemic inflammation on bone, and to date a variety of different doses, routes, and ...

4 天之前 · Acute lung injury (ALI) is a severe respiratory disorder associated with high morbidity and mortality. Lipopolysaccharide (LPS) is widely used to induce ALI in animal models. D-carvone, a natural monoterpene, has been reported to possess anti-inflammatory and antioxidant properties. This study aimed to investigate the protective effects of D-carvone on LPS-induced ALI in rats. Thirty-six male ...

2020年2月5日 · This review summarizes the current evidence and highlights uncertainties on the molecular dynamics of LPS-induced lung injury in rodent models, encouraging researchers to take accurate timing of LPS-induced injury into account when designing experimental trials.

The intraperitoneal application of lipopolysaccharide (LPS) alone or in combination with other hepatotoxins is an experimental model for inducing systemic and hepatic inflammation in rodents applied worldwide. The endotoxin is recognized by the LPS-binding protein.

2021年4月8日 · We conclude that an intranasal exposure is as effective as an intratracheal exposure in a murine model of ARDS induced by LPS. Additionally, the groups exposed intranasally demonstrated...