To mimic the entrance of bacterial-derived compounds into the host, an endotoxemia model has been adopted in which lipopolysaccharide (LPS), a component of the outer cell wall of Gram-negative bacteria, were injected into mice. In this study, a sublethal dose of LPS was intraperitoneally injected and the mice were subsequently monitored for 8 h ...

2019年4月8日 · We found that LPS treatment leads to sickness behavior and cognitive impairment in mice as shown in the Morris water maze and passive avoidance test, and these effects were accompanied by...

This study was designed to define the lipopolysaccharide (LPS) sensitivity of aged mice in terms of lethality and cytokine production and to determine down-regulating responses of corticosterone and interleukin 10 (IL-10). The 50% lethal doses of LPS in young (6- to 7-week-old) and aged (98- …

2025年3月20日 · Tm loads in mice systemically exposed to PBS or LPS or orally pre-treated with streptomycin (strep.)(minimum mice n = 8, at least two independent replicates, *** P = 0.0002). c Number of S .

2020年2月4日 · This review describes the molecular mechanisms that contribute to lung injury in rodent models of LPS-induced organ injury mimicking either pulmonary or extra-pulmonary ARDS. Pathways of LPS-induced lung injury are not only affected by the type of the primary insult and the presence of additional stimuli but also by time.

2020年8月1日 · We have compared inflammation-induced sickness behavior in rodents and humans. LPS-induced signs of sickness in rodents and humans appear to follow similar patterns. Depressive- and anxiety-like behaviors cannot be compared in a straightforward manner between rodents and humans.

2023年10月13日 · LPS activates the RAS-RAF-mitogen-activated protein kinase/ERK kinase (MEK)-extracellular-signal-regulated kinase (ERK) signaling cascade in macrophages. The purpose of this study was to examine...

Bacterial endotoxin lipopolysaccharide (LPS) often results in multiple organ failure. However, pre-exposure of mice to a sublethal dose of LPS renders the animal tolerant to a lethal dose of LPS. This study was designed to determine whether pre-exposure of …

2020年2月5日 · This review summarizes the current evidence and highlights uncertainties on the molecular dynamics of LPS-induced lung injury in rodent models, encouraging researchers to take accurate timing of LPS-induced injury into account when designing experimental trials.

2024年2月15日 · Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1beta and anti-inflammatory IL-10 cytokines