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2005年11月1日 · Here, we demonstrate that IRF-4 negatively regulates the production of proinflammatory cytokines by macrophages in response to Toll-like receptor (TLR) stimulation. Mice lacking IRF-4 are sensitive to LPS-induced shock, and their macrophages produce high levels of proinflammatory cytokines, including TNF-α and IL-6, in response to TLR ligands.

2022年11月22日 · Having detected cholesterol accumulation within lysosomal/endosomal regions after LPS stimulation, we tested the idea that cellular cholesterol accumulation is causally required for macrophage activation by assessing proinflammatory gene expression in RAW cells treated with mevastatin or chloroquine followed by LPS.

2005年11月1日 · Here, we demonstrate that IRF-4 negatively regulates the production of proinflammatory cytokines by macrophages in response to Toll-like receptor (TLR) stimulation. Mice lacking IRF-4 are sensitive to LPS-induced shock, and their macrophages produce high levels of proinflammatory cytokines, including TNF-alpha and IL-6, in response to TLR ligands.

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2023年12月6日 · LPS (脂多糖)由一个被称为 脂质A 的特定碳水化合物脂质片段锚定在细菌外膜的多糖区域组成。 脂质A是一种与羟基脂肪酸相连的葡萄糖胺双糖，羟基脂肪酸进一步被非羟基脂肪酸取代。