表皮生长因子受体 （Epidermal Growth Factor Receptor, EGFR）是一种跨膜受体酪氨酸激酶，参与调节巨噬细胞 LPS /TLR4信号传导 [3]。 唐靖 课题组前期研究也发现，EGFR磷酸化协同TLR4调节 内毒素血症 中巨噬细胞的激活 [4]。

2022年11月7日 · Here, we show that LPS promotes high levels cell surface expression of EGFR in macrophages through two different transport mechanisms. On one hand, Rab10 is required for EEA1-mediated the...

Here, we show that LPS promotes high levels cell surface expression of EGFR in macrophages through two different transport mechanisms. On one hand, Rab10 is required for EEA1mediated the membrane translocation of EGFR from the Golgi. On the other hand, EGFR phosphorylation prevents its endocytosis in a kinase activity-dependent manner.

Epidermal growth factor receptor (EGFR) activation prevents experimental NEC and may play a critical role in LPS-stimulated COX-2 production. We hypothesized that EGFR is required for LPS induction of COX-2 expression. Our data show that inhibiting EGFR kinase activity blocks LPS-induced COX-2 expression in small intestinal epithelial cells.

2022年11月7日 · Here, we show that LPS promotes high levels cell surface expression of EGFR in macrophages through two different transport mechanisms. On one hand, Rab10 is required for EEA1-mediated the membrane translocation of EGFR from the Golgi. On the other hand, EGFR phosphorylation prevents its endocytosis in a kinase activity-dependent manner.

In this study, we investigated the effects of EGFR inhibition on lipopolysaccharides (LPS)-induced ALI in rats. In addition, we evaluated the anti-inflammatory effects of EGFR inhibition or silence in vitro, as well as the mechanism of LPS-induced activation of EGFR.

2015年8月4日 · In mice, erlotinib blocks the LPS-induced expression of tumor necrosis factor α (TNFα) and interleukin-6 (IL-6) and ameliorates LPS-induced endotoxity, revealing that EGFR is essential for LPS-induced signaling in vivo.

2020年7月20日 · TLR4, as an on-membrane receptor of LPS, plays a crucial part in the process of sepsis, and EGFR phosphorylation promotes cell inflammation in response to LPS, which plays an indispensable role in modulating LPS/TLR4 signaling pathway.

2024年4月1日 · In the present study, we report that LPS induces EGFR activation through TLR4/TACE/TGF-α signaling, leading to LOX overactivation and Cdc42 inhibition, and disrupts elastin deposition and localization, eventually resulting in alveolar developmental arrest.

2012年5月31日 · Our data show that inhibiting EGFR kinase activity blocks LPS-induced COX-2 expression in small intestinal epithelial cells. LPS induction of COX-2 requires Src-family kinase signaling while LPS transactivation of EGFR requires matrix metalloprotease (MMP) activity.