脂多糖 （Lipopolysaccharide, LPS）是革兰氏阴性细菌外膜的重要成分，对细菌的生存和致病性具有重要影响。LPS位于细菌外膜的外层，在无荚膜菌株中直接暴露在细胞表面。

Intact bacterial lipopolysaccharides are macromolecules of molecular mass 10‑20 kDa made up of three structural components (Figure 1): A hydrophobic lipid section, lipid A, which is responsible for the toxic properties of the molecule, A hydrophilic core polysaccharide chain, and

Using a photoactivable, radioiodinated lipopolysaccharide probe, [125I]ASD-LPS (derivatized from purified E. coli 0111:B4 S-LPS), we earlier reported the presence of a 73-kDa (p73) predominant LPS-binding protein on mouse lymphocytes and macrophages with specificity for …

2021年2月1日 · High IgG antibody levels to H. pylori LPSs were observed in sera from H. pylori -infected cases. The structural diversity of the lipopolysaccharides (LPSs) from Helicobacter pylori poses a challenge to establish accurate and strain-specific structure-function relationships in interactions with the host.

2025年3月7日 · Both the 35-kDa band (present only upon ligand binding) and the 20-kDa band (present in the absence of ligand) lacked peptides C-terminal to R265 . These data suggest that binding of LPS or PGPC induces a common conformational change in the CARD that transforms it from a trypsin-sensitive to an α-helical trypsin-resistant state.

When the LPS is treated with SDS and heat, the molecular weight is in the range of 50 to 100 kDa. In their purest form, in the presence of strong surface active agents, and in the absence of divalent cations, bacterial endotoxins consist of 10-20 kDa macromolecules.

When the LPS is treated with SDS and heat, the molecular weight is in the range of 50 to 100 kDa. In their purest form, in the presence of strong surface active agents, and in the absence of divalent cations, bacterial endotoxins consist of 10-20 kDa macromolecules.

1 天前 · In contrast, leaked proIL-1 β from LPS-primed microglia after ATP stimulation is processed into the 20 kDa form of IL-1 β by cathepsin D [39,40]. Interestingly, the formation of the 20 kDa form of IL-1 β prevents the generation of mature IL-1 β and thus may limit inflammation, because the 20 kDa form of IL-1 β is minimally active at IL-1R1 ...

1993年6月1日 · Using a photoactivable, radioiodinated lipopolysaccharide probe, [125 I]ASD-LPS (derivatized from purified E. coli 0111:B4 S-LPS), we earlier reported the presence of a 73-kDa (p73) predominant LPS-binding protein on mouse lymphocytes and macrophages with specificity for the lipid A region of LPS.

2024年3月31日 · 内毒素是有毒的脂多糖（lps），从革兰氏阴性细菌的外膜延伸出来，因其毒性和有害作用而臭名昭著。从各种革兰氏阴性细菌中分离出的不同 lps 的比较显示出整体相似的结构，对应于糖脂脂质 a 部分、核心寡糖和分子量为 2 至 20 kda 的最外层长 o 链多糖。 lps在属和种之间表现出高度的多样性和特异 ...