We found that LPS induced the expression levels of IL-1β, IL-6 and iNOS, and induced the production of ROS and MDA, indicating LPS caused an inflammatory response and oxidative stress in KGN cells. And we found the miR-873-5p expression was up-regulated in the LPS-induced KGN cells.

2018年11月11日 · Flow cytometry indicated that miR-873-5p inhibitor suppressed cell apoptosis in LPS-induced KGN cells. Besides, miR-873-5p inhibitor resulted in a decrease in oxidative stress, which was evidenced by the reduced production of reactive oxygen species (ROS) and malondialdehyde (MDA).

脂多糖（Lipopolysaccharide, LPS）是革兰氏阴性细菌外膜的主要成分之一，由类脂A、核心多糖和O-抗原三部分组成，其中O-抗原决定了LPS的血清型，具有重要的生物学功能和作用机制。

2020年7月16日 · We showed that (i) the miR-873 sponge significantly ameliorated the LPS-induced accumulation of α-synuclein and loss of DA neurons in the SN; (ii) miR-873 was a key mediator of the inhibition of ABCA1 by LPS through the TLR4-MyD88 signaling pathway; (iii) miR-873 transfection or ABCA1 silencing resulted in the accumulation of α-synuclein in ...

2022年2月2日 · Expression of concern for ‘MiR-873-5p regulated LPS-induced oxidative stress via targeting heme oxygenase-1 (HO-1) in KGN cells’ by Hui Zhang et al., RSC Adv., 2018, 8, 39098–39105. DOI: 10.1039/C8RA06697C.

Here, we investigated the effects of miR-873 on lysosomal cholesterol homeostasis and progressive dopaminergic neuron damage in a lipopolysaccharide-(LPS) induced model of PD. Experimental Approach. To evaluate the therapeutic benefit of the miR-873 spong

Lipopolysaccharides（脂多糖），简称为LPS ，革兰氏阴性菌（G-）细胞壁中的一种特有成分，位于细胞壁的最外层并暴露于非荚膜细菌的细胞表面，有利于维持细胞外膜的完整性，保护细菌免受胆汁盐和脂类抗生素的损害。LPS由类脂A、核心多糖和O-多糖侧链组成。

LPS（Lipopolysaccharides，脂多糖）是革兰阴性菌细胞壁的一种成分，在科研中也是诱导细胞炎症反应的常用试剂。 但是在接触LPS的过程中，难免会遇上一些疑惑，以下是自己记录一些笔记。

2024年6月12日 · 脂多糖(英文简写lps) 是革兰氏阴性细菌细胞壁外壁的组成成分，是由脂质和多糖构成的物质(糖脂质)。脂多糖由三部分组成:类脂a、核心多糖、o-抗原。 脂多糖由三部分组成:类脂A、核心多糖、O-抗原。

Fisher, Laura (2022) Expression of concern: MiR-873-5p regulated LPS-induced oxidative stress via targeting heme oxygenase-1 (HO-1) in KGN cells. RSC Advances, 12 (8) 4778 doi:10.1039/d2ra90009b