脂多糖（Lipopolysaccharide, LPS）是革兰氏阴性细菌外膜的主要成分之一，由类脂A、核心多糖和O-抗原三部分组成，其中O-抗原决定了LPS的血清型，具有重要的生物学功能和作用机制。

脂多糖是一种常见的内毒素 (Endotoxin)，在体内可以通过细胞信号转导系统激活单核巨噬细胞、内皮细胞、上皮细胞等，合成和释放多种细胞因子和炎性介质，进而引起机体一系列的反应。 其主要作用机理已研究的较为透彻，如图2所示，当LPS进入机体入血后，脂多糖结合蛋白LBP可以识别LPS，与LPS单体结合运送至 髓源性细胞 表面。 髓源性细胞表面的mCD14与之结合，形成LPS-LBP-CD14三联复合体，随后将其转运至TLR4-MD2蛋白复合体处，三联复合体在MD-2的帮助 …

LPS is known to mimic the pathophysiology of gram-negative bacterial infections, the combined treatment of LPS and D-GalN is a widely acknowledged hepatic injury model 26,27. The results of this study suggest that co-administration of LPS/D-GalN has strong genotoxic effect in mouse liver, as evidenced by a noteworthy increase in tail DNA ...

Bacterial lipopolysaccharides (LPS) typically consist of a hydrophobic domain known as lipid A (or endotoxin), a nonrepeating "core" oligosaccharide, and a distal polysaccharide (or O-antigen). Recent genomic data have facilitated study of LPS assembly in diverse Gram-negative bacteria, many of whic …

Lipopolysaccharide (LPS), also known as endotoxin, is a structural component of the cell wall of gram-negative bacteria. It is a large protein ranging from 50-100 kDaltons in size. LPS can cause a strong immune response, particularly in the respiratory tract after aerosol exposure.

2022年11月1日 · Lipopolysaccharide (LPS) is a cell-wall component of Gram-negative bacteria which contributes to bacterial toxicity. During processes such as cell division, shedding of outer membrane vesicles, or bacterial cell death, LPS is released into the surrounding media.

脂多糖 （Lipopolysaccharide, LPS）是革兰氏阴性细菌外膜的重要成分，对细菌的生存和致病性具有重要影响。LPS位于细菌外膜的外层，在无荚膜菌株中直接暴露在细胞表面。

Lipopolysaccharide (LPS) or endotoxin, the major cell wall component of Gram-negative bacteria, plays a pivotal role in the pathogenesis of sepsis. It is able to activate the host defense system through interaction with Toll-like receptor 4, thus triggering pro-inflammatory mechanisms.

2024年3月16日 · LPS, commonly known as endotoxin, is a complex molecule primarily found in the outer membrane of Gram-negative bacteria, and has a crucial role in triggering inflammatory responses. Recent studies have illuminated LPS delivery systems used by both pathogens and hosts, providing insights into host–pathogen interactions.

2014年11月25日 · Lipopolysaccharide (LPS，脂多糖)，俗称为内毒素，是革兰氏阴性菌细胞壁的主要成分。 LPS也是病原菌最为重要的模式分子，可诱导严重免疫反应，是败血症和内毒素性休克最主要的诱因。