Lipopolysaccharides can have substantial impacts on human health, primarily through interactions with the immune system. LPS is a potent activator of the immune system and is a pyrogen (agent that causes fever). [4] In severe cases, LPS can trigger a brisk host response and multiple types of acute organ failure [5] which can lead to septic ...

2020年7月30日 · Lipopolysaccharide (LPS), a constituent of the outer membrane of Gram-negative bacteria, is a trigger of inflammation and the dysregulated host response in sepsis. Human LPS models deliver a small quantity of LPS to healthy volunteers, triggering an inflammatory response and providing a window to study early inflammation in humans.

2024年3月16日 · Lipopolysaccharide (LPS), a key component of the outer membrane in Gram-negative bacteria (GNB), is widely recognized for its crucial role in mammalian innate immunity and its link to mortality in intensive care units.

Intradermal LPS administration in humans causes an acute, localized and transient inflammatory reaction that is well-tolerated by healthy volunteers. This may be a valuable inflammation model for evaluating the pharmacological activity of anti-inflammatory investigational compounds in …

Lipopolysaccharide (LPS) is the main structural component of the outer membrane of most Gram-negative bacteria and has diverse immunostimulatory and procoagulant effects. Even though LPS is well described for its role in the pathology of sepsis, ...

Lipopolysaccharide (LPS [endotoxin]) is the principal component of the outer membrane of Gram-negative bacteria. Recent studies have elucidated how LPS is recognized by monocytes and macrophages of the innate immune system. Human monocytes are exquisitely sensitive to LPS and respond by expressing m …

2012年1月12日 · In this study we demonstrate that LPS-stimulated release of proinflammatory cytokines from human monocytes is mediated through the activation of PI3K in both a ROS- and a G-protein-dependent manner, propagated through NOX4 activation.

Lipopolysaccharides (LPS) have been found to adversely impact human health in various ways. In this section, we will discuss the role of LPS in sepsis and septic shock, inflammatory and autoimmune disorders, obesity and metabolic disorders, and mental health issues.

2024年10月28日 · Lipopolysaccharides (LPS) are complex molecules found in the outer membrane of Gram-negative bacteria, impacting bacterial physiology and pathogenesis. Understanding LPS is important due to its role in triggering immune responses that may lead to inflammation or sepsis.

2015年2月6日 · This article reviews immunogenicity and safety data pertaining to LPS administration, with a particular focus on LPS inhalation, which may facilitate the optimization of its use in human research.