The aims of this study were to establish a model of intra-amniotic lipopolysaccharide (LPS)-induced preterm labor/birth that resembles the subclinical syndrome and to compare this model to two established models of LPS-induced preterm labor/birth.

Herein we investigated the effect of N -acetyl cysteine (NAC) on lipopolysaccharide (LPS)-induced preterm labor and fetal demise in murine model. Lipopolysaccharide exposure at embryonic day 18...

2007年5月20日 · The effects of LPS on preterm labor are presented in Fig. 1 A. Results showed that administration of a single dose LPS (120 μg/kg, i.p.) on gd 15 resulted in 26.7% (4/15) pregnant mice delivered before gd 18.

We report that exosomal delivery of SR delayed lipopolysaccharide (LPS)–induced PTB, and this was associated with a reduction in fetal innate cell migration and the inflammatory response in …

In various animal models of preterm labor (PTL), the Gram-negative bacterial cell wall component, lipopolysaccharide (LPS), is administered systemically to mimic bacterial infection during pregnancy or locally via an intrauterine injection to reflect ascending vaginal infection and/or chorioamnionitis. 10–21 Recognition of the LPS molecule by ...

An hour after the first EPO or normal saline injection, all mice received two injections of 50 μg/kg LPS, also given 3 hours apart. Results: EPO significantly prevented preterm labor and increased offspring survival in an LPS induced preterm delivery model.

Intrauterine or intraperitoneal administration of lipopolysaccharide (LPS) into normal mice at midgestation induces preterm delivery (PTD) within 24 h through a mechanism dependent on Toll-like receptor signaling and expression of inflammatory cytokines. The exact participants in the cellular network involved in PTD are not known.

2018年8月22日 · LPS-induced maternal endotoxemia promotes IUFD, PTB, and fetal leukocyte recruitment depending on gestational age. Our proposed model may serve as a platform to test novel perinatal...

2007年5月20日 · Lipopolysaccharide (LPS) has been associated with adverse developmental outcome, including embryonic resorption, intra-uterine fetal death (IUFD), intra-uterine growth retardation (IUGR) and preterm delivery in rodents. The purpose of the present study was to investigate whether administration of a …

2020年6月7日 · Our study first indicates that EPO increased the expression of placental PD-L1 in preventing LPS-induced preterm labor, suggesting that EPO might activate the JAK2/STAT3 signaling pathway and promote the expression of PDL1 protein to prevent preterm labor.