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2024年4月7日 · Treatment with LQT-1213 significantly reduced DOF-induced QT prolongation, without safety issues. The WAVE I study provides evidence that the SGK1 inhibitor LQT-1213 could shorten the QT intervals in patients with LQTS and drug induced QT prolongation, providing proof of concept for a novel, mechanistic-based targeted therapy.

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2023年10月2日 · 作者您好，最近希望借助【LQT with control primitives and DMP】中的代码对我们的数据进行处理，进行试验后发现这一节所采用的示例文件S.npy为三维numpy数组形式， …

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LQTS通常是一种常规染色体显性遗传疾病，定位于染色体11上的LQT1发生突变，导致自己心脏钾离子通道发生严重缺陷，不能把电子传导脉冲至整个心脏。 还可能存在其它基因，不确定地定位于染色体3、6和11，它的突变产物可能导致或引发LQT综合症。 Beta封闭剂常用于治疗疾病综合症，并对某些综合症病人产生效果。 然而，普遍有效的治疗方法，比如避免激烈的体育锻炼和其它压力仍是有效的。 有关上述讨论基因如何相互作用的研究应为LONG-QT治疗加速新的开发。 …

We read the updated 2022 European Society of Cardiology (ESC) guidelines on the management of patients with long QT syndrome (LQTS) to prevent the occurrence of life-threatening ventricular arrhythmia (VA) and/or sudden cardiac death (SCD) (Table 1) [1].

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