2013年8月15日 · The IFN-inducible protein Irgm1 (LRG-47) belongs to the family of immunity-related GTPases that function in cell-autonomous resistance against intracellular pathogens in mice. Irgm1 deficiency is associated with a severe immunodeficiency syndrome.

2008年1月10日 · We report that the interferon-inducible GTPase Lrg-47 (Irgm1), previously shown to play a critical role in host defense, inhibits baseline HSC proliferation and is required for a normal HSC response to chemical and infectious stimuli.

2003年10月24日 · Here, we identify one member of a newly emerging 47-kilodalton (p47) guanosine triphosphatase family, LRG-47, that acts independently of NOS2 to protect against disease. Mice lacking LRG-47 failed to control Mtb replication, unlike those missing the related p47 guanosine triphosphatases IRG-47 or IGTP.

2003年10月24日 · Here, we identify one member of a newly emerging 47-kilodalton (p47) guanosine triphosphatase family, LRG-47, that acts independently of NOS2 to protect against disease. Mice lacking LRG-47 failed to control Mtb replication, unlike …

小鼠Irgm1是一个分子量为47 000的干扰素(interferon，IFN)-γ诱导性免疫相关的GTP酶蛋白，广泛表达于细胞内的高尔基体或者内质网上 。小鼠Irgm1率先被证实参与抗寄生虫或抗菌感染治疗过程中。

2006年9月8日 · We found that the murine Irgm1 (LRG-47) guanosine triphosphatase induced autophagy and generated large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. We also identified a function for a human IRG protein in the control of intracellular pathogens and report that the human Irgm1 ortholog ...

2001年7月16日 · After infection with L. monocytogenes, LRG-47-deficient mice exhibited a profound loss of resistance, whereas IRG-47-deficient mice exhibited completely normal resistance. In addition, both strains displayed normal clearance of MCMV. Thus, LRG-47 and IRG-47 have vital, but distinct roles in immune defense against protozoan and bacterial infections.

2004年8月15日 · In this study, we show that LRG-47 is a Golgi-associated protein in the IFN-stimulated cell, which is rapidly recruited to active plasma membrane upon phagocytosis and remains associated with phagosomes as they mature.

2004年1月15日 · LRG-47 −/− and control B6129 animals (n = 4 mice/group) were infected aerogenically with 100 CFU of M. tuberculosis (Erdman strain), and pulmonary bacterial loads (A) and lymphocyte numbers in mediastinial lymph nodes (B) were determined 4 wk later. The data shown are the mean ± SD for each group of animals.

LRG-47 and IRG-47 belong to a family of IFN-γ–induced proteins whose expression is increased to very high levels in mice after infection with numerous pathogens, including T. gondii, L. monocytogenes, and MCMV .