Leucine-rich alpha-2-glycoprotein 1 is a protein which in humans is encoded by the gene LRG1. [5] The leucine-rich repeat (LRR) family of proteins, including LRG1, have been shown to be …

2024年12月25日 · LRG1 (Leucine Rich Alpha-2-Glycoprotein 1) is a Protein Coding gene. Diseases associated with LRG1 include Appendicitis and Cecal Disease. Among its related …

2022年1月21日 · 大约十年前，分泌性富含亮氨酸的 α-2 糖蛋白 1 (LRG1) 首次被描述为致病性眼部新生血管形成的关键参与者。 从那时起，越来越多的出版物报道了 LRG1 与多种人类疾病 …

2025年2月25日 · Leucine-rich alpha-2-glycoprotein 1 (LRG1), a secretory glycoprotein associated with angiogenesis, inflammation, fibrosis, and other pivotal pathophysiological processes, is …

2022年1月21日 · Leucine-rich α-2 glycoprotein 1 (LRG1) is a secreted member of the family of leucine-rich repeat (LRR) proteins and was first discovered in human serum in 1977 [1]. The …

2013年7月17日 · LRG1 is identified as a new regulator of TGF-β signalling that promotes angiogenesis via a TβRII–ALK1–ENG–Smad1/5/8 signalling pathway; antibody-mediated …

2022年1月21日 · The secreted glycoprotein leucine-rich α-2 glycoprotein 1 (LRG1) was first described as a key player in pathogenic ocular neovascularization almost a decade ago. Since …

2023年5月1日 · Here, we determined the crystal structure of LRG1, identifying the horseshoe-like solenoid structure of LRG1 and its four N-glycosylation sites.

2025年2月8日 · LRG1 plays a crucial role in the proliferation and apoptosis of colorectal cancer (CRC) by regulating RUNX1 expression. LRG1 may be a potential detection biomarker as well …

LRG1 is a novel HER3 ligand and mediates liver-mCRC crosstalk. The LRG1-HER3 signaling axis is distinct from canonical HER3 signaling and represents a new therapeutic opportunity to treat …