The liver receptor homolog-1 (LRH-1) also known as totipotency pioneer factor NR5A2 (nuclear receptor subfamily 5, group A, member 2) is a protein that in humans is encoded by the NR5A2 gene. [5] [6] LRH-1 is a member of the nuclear receptor family of intracellular transcription factors.

LRH-1（Liver receptor homolog-1），肝受体同源物-1。 LRH-1是一种配体激活的转录因子，属于核受体蛋白家族。 激活CYP7A1表达的转录因子。 LRH-1 通常充当单体，并且在没有配体的情况下似乎也具有高组成型转录诱导剂活性。 长期以来，它被认为是一种孤儿核受体（orphan nuclear receptor），但最终发现磷脂是具有潜在生理相关性的内源性LRH-1配体。 IR-1（inverted repeat-1），FXR 受体的结合反应元件。 BESP（bile salt export pump）, 胆盐输出泵。 属于ATP结合 …

2024年4月17日 · Liver receptor homolog-1 (LRH-1), a member of the nuclear receptor superfamily, is a ligand-regulated transcription factor that plays crucial roles in...

肝受体同源物-1 (LRH-1, NR5A2) 是一种配体激活的转录因子，属于核受体蛋白家族。 它也被称为 fushi tarazu因子1 （FTZ-F1）、甲胎蛋白转录因子（FTF）、胰腺同源受体1（PHR-1）、人B1结合因子（hB1F）、激活增强子II的肝细胞转录因子乙型肝炎病毒 (HB1F2) 和 Cyp7A 启动子结合因子 (CPF)。 LRH-1属于核受体亚家族5 A组 (NR5A)，这一家族蛋白还包含与人类密切相关的类固醇生成因子1（SF-1，NR5A1），而其他物种（例如，果蝇）具有更多NR5A亚科成员。 LRH-1 …

2021年8月1日 · LRH-1 is a key regulator of bile acid, lipid, glucose and methyl group homeostasis. LRH-1 coordinates several cellular stress responses in the liver. LRH-1 is a potential target for the prevention and treatment of NAFLD and HCC.

2020年2月28日 · Liver receptor homolog-1 (LRH-1, Nr5a2) is an orphan nuclear receptor mainly expressed in tissues of endodermal origin, where its physiological role has been...

2004年5月1日 · The liver receptor homolog-1 (LRH-1; NR5A2) and steroidogenic factor-1 (SF-1; NR5A1) are two orphan members of the Ftz-F1 subfamily of nuclear receptors. LRH-1 is expressed in tissues derived from endoderm, including intestine, liver and exocrine pancreas, as well as in the ovary.

Liver receptor homolog-1 (LRH-1), a member of the nuclear receptor superfamily, is a ligand-regulated transcription factor that plays crucial roles in metabolism, development, and immunity. Despite being classified as an 'orphan' receptor due to the ongoing debate surrounding its endogenous ligands, …

2004年5月1日 · The metabolic pathways controlled by liver receptor homolog-1 (LRH-1). LRH-1 plays a key role in metabolism because several of its target genes are crucial to the regulation of different pathways of cholesterol and bile acid (BA) homeostasis, such as reverse cholesterol transport, BA synthesis, and enterohepatic circulation.

The liver receptor homolog-1 (LRH-1; NR5A2) and steroidogenic factor-1 (SF-1; NR5A1) are two orphan members of the Ftz-F1 subfamily of nuclear receptors. LRH-1 is expressed in tissues derived from endoderm, including intestine, liver and exocrine pancreas, as well as in the ovary.