KDM1A - Wikipedia
Lysine-specific histone demethylase 1A (LSD1) also known as lysine (K)-specific demethylase 1A (KDM1A) is a protein that in humans is encoded by the KDM1A gene. [5] LSD1 is a flavin-dependent monoamine oxidase, which can demethylate mono- and di-methylated lysines, specifically histone 3, lysine 4 (H3K4).
Nature子刊：LSD1 在调节增强子和细胞命运转变中的独立去甲基 …
LSD1是第一个被识别的组蛋白赖氨酸去甲基酶，它靶向增强子并通过其黄素腺嘌呤二核苷酸 (FAD) 依赖性胺氧化酶活性去除H3K4me1/2。 LSD1是转录共抑制复合物CoREST的一个组成部分，该复合物包含接头蛋白 RCOR1 和组蛋白脱乙酰酶 HDAC1 和 HDAC2。 RCOR1直接与HDAC1/2和LSD1相互作用，将两个酶部分桥接成一个蛋白质复合物。 CoREST 的这种双重酶作用被认为对于基因抑制至关重要。 除了在胚胎发生和分化中的重要性之外，LSD1还与发育障碍、炎症性疾 …
组蛋白去甲基化酶：LSD和JmjC家族 - 华美生物
2024年2月5日 · lsd1又称kdm1a或aof2，是第一个被发现的组蛋白赖氨酸去甲基化酶，它能去除组蛋白h3中赖氨酸4（h3k4me1/2）或组蛋白h3中赖氨酸9（h3k9me1/2）上的单甲基和二甲基基团，分别作为基因表达的抑制因子或激活因子。
Cell丨施扬组报道抗肿瘤免疫与治疗新靶点——曹雪涛院士点评
体内研究表明，敲除肿瘤细胞lsd1能够增加肿瘤内t细胞浸润及其抗肿瘤效应。利用原本对pd-(l)1抑制剂治疗无效的小鼠b16黑色素瘤模型，发现当敲除肿瘤细胞lsd1后再给予pd-1抑制剂治疗，可以显著抑制b16黑色素瘤生长。该研究团队利用公共数据库分析发现，多种 ...
LSD1: more than demethylation of histone lysine residues
2020年12月14日 · LSD1, also known as KDM1A (lysine-specific demethylase 1A) or AOF2 (flavin-containing amine oxidase domain-containing protein 2), is an 852 amino acid flavin-dependent monoamine oxidase (MAO)...
Roles of lysine-specific demethylase 1 (LSD1) in homeostasis and ...
2021年6月4日 · Lysine-specific demethylase 1 (LSD1) targets mono- or di-methylated histone H3K4 and H3K9 as well as non-histone substrates and functions in the regulation of gene expression as a transcriptional repressor or activator.
组蛋白去甲基化酶LSD1及其生物学功能 - chinagene.cn
摘要： 赖氨酸特异性组蛋白去甲基化酶1(Lysine specific demethylase 1, LSD1) 的发现, 表明组蛋白的甲基化修饰是一个动态可调节的过程。结构分析显示, LSD1 是一个黄素腺嘌呤二核苷酸(Flavin adenine dinulcleotide, FAD) 依赖性胺氧化酶, 它能够特异性脱去单甲基化和二甲基化组 ...
LSD1: biologic roles and therapeutic targeting - PMC - PubMed …
LSD1 (KDM1A; BHC110; AOF2) was the first protein reported to exhibit histone demethylase activity and has since been shown to have multiple essential roles in mammalian biology. Given its enzymatic activity and its high-level expression in many human malignancies, a significant recent focus has been the development of pharmacologic inhibitors.
LSD1 Ablation Stimulates Anti-tumor Immunity and Enables …
Ablating the histone demethylase LSD1 genetically or pharmacologically enhances tumor immunogenicity by stimulating endogenous retrovirus expression and downregulating RNA-induced silencing complex, supporting the promise of LSD1 inhibition in overcoming resistance to checkpoint blockade in cancer treatment.
【APSB综述】靶向组蛋白去甲基化酶LSD1的调控新策略
2024年1月16日 · lsd1作为第一个组蛋白去甲基化酶，其失调与肿瘤恶性转化、emt、细胞增殖和分化等密切相关，被认为是癌症、神经退行性疾病、病毒感染等多种疾病的重要靶标。