LTB 4 is a leukotriene involved in inflammation. It is produced from leukocytes in response to inflammatory mediators and is able to induce the adhesion and activation of leukocytes on the endothelium, allowing them to bind to and cross it into the tissue. [1] .

Leukotriene B4 (LTB4) is a major type of lipid mediator that is rapidly generated from arachidonic acid through sequential action of 5-lipoxygenase (5-LO), 5-lipoxygenase-activating protein (FLAP) and LTA4 hydrolase (LTA4H) in response to various stimuli.

Leukotriene B 4 (LTB4) is a proinflammatory lipid mediator generated from arachidonic acid through the sequential activities of 5–lipoxygenase, 5–lipoxygenase–activating protein, and leukotriene A 4 hydrolase 16.

LTB4 is a potent chemoattractant, facilitating leukocyte adhesion and recruitment and its role in the pathogenesis of atherosclerosis is well established. LTA4 can be conjugated with glutathione through the enzyme LTC4 synthase to produce Leukotriene C4 (LTC4).

Leukotriene B4 is a leukotriene composed of (6Z,8E,10E,14Z)-icosatetraenoic acid having (5S)- and (12R)-hydroxy substituents. It is a lipid mediator of inflammation that is generated from arachidonic acid via the 5-lipoxygenase pathway. It has a role as a human metabolite, a mouse metabolite, a plant metabolite and a vasoconstrictor agent.

Leukotriene B 4 (LTB 4) is an endogenous lipid mediator of inflammation derived from arachidonic acid by the sequential action of cytosolic phospholipase A 2 and 5-lipoxygenase. This mediator was initially recognized for its involvement in the recruitment of neutrophils.

Leukotriene B 4 (LTB 4), a lipid mediator produced from arachidonic acid, is a chemoattractant for inflammatory leukocytes. We identified two receptors for LTB 4, the high-affinity receptor BLT1 and the low-affinity receptor BLT2.

Directed leukocyte migration is a hallmark of inflammatory immune responses. Leukotrienes are derived from arachidonic acid and represent a class of potent lipid mediators of leukocyte migration. In this review, we summarize the essential steps leading to the production of LTB 4 …

Aug 1, 2023 · Leukotriene B 4 (LTB 4) is a potent lipid chemoattractant driving inflammatory responses during host defense, allergy, autoimmune and metabolic diseases. Gradients of LTB 4 orchestrate...

May 15, 2012 · Leukotriene B4 (LTB4) is a potent chemoattractant secreted by neutrophils in response to formyl peptides. We demonstrate that LTB4 significantly amplifies neutrophil recruitment to primary chemoattractants by selectively modulating signaling cascades involved in cell polarization and by serving as a potent secondary gradient.